Changes in Prescription Drug and Health Care Use Over 9 Years After the Large Drug Price Increase for Colchicine.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2023.0898
Abstract: Importance Prescription drug prices are a leading concern among patients and policy makers. There have been large and sharp price increases for some drugs, but the long-term implications of large drug price increases remain poorly… read more here.
Keywords: rheumatology; increase; colchicine; price ... See more keywords
Effect of Colchicine vs Usual Care Alone on Intubation and 28-Day Mortality in Patients Hospitalized With COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.41328
Abstract: Key Points Question Does colchicine prevent intubation and mortality in hospitalized patients with COVID-19 pneumonia? Findings In this randomized clinical trial of 1279 patients hospitalized with COVID-19, patients allocated to receive colchicine plus usual care… read more here.
Keywords: usual care; hospitalized covid; mortality; day mortality ... See more keywords
Colchicine, a microtubule‐disassembling drug, in the therapy of cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10988
Abstract: Colchicum autumnale, from which colchicine has been isolated more than 100 years ago, has been used as a treatment for pain and swelling for thousands of years. It is one of the few drugs known… read more here.
Keywords: drug; colchicine; therapy cardiovascular; cardiovascular diseases ... See more keywords
Safety and efficacy of intravenous Colchicine in children with Familial Mediterranean Fever
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology International"
DOI: 10.1007/s00296-019-04348-y
Abstract: Familial Mediterranean Fever (FMF), the most common monogenic inflammatory disease, is mainly treated by oral Colchicine. However, 5% of patients are considered non-responders and, therefore, candidates for biologic therapy. Intravenous (IV) Colchicine treatment has been… read more here.
Keywords: familial mediterranean; safety; colchicine; intravenous colchicine ... See more keywords
Different pharmaceutical preparations of colchicine for Familial Mediterranean Fever: are they the same?
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology International"
DOI: 10.1007/s00296-019-04432-3
Abstract: This study aimed to investigate the benefit of changing the pharmaceutical preparation of colchicine in Turkish Familial Mediterranean Fever (FMF) patients resistant to one preparation in terms of frequency of the attacks. Turkish adult FMF… read more here.
Keywords: familial mediterranean; treatment; colchicine; preparations colchicine ... See more keywords
Colchicine may not be effective in COVID-19 infection; it may even be harmful?
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05144-x
Abstract: Dear Editor, Nowadays, the novel coronavirus disease 2019 (COVID19) pandemic is spreading rapidly all over the world. The search for drugs against COVID-19 is continuing. Colchicine is used in many inflammatory diseases such as familial… read more here.
Keywords: infection; effect; colchicine; viral load ... See more keywords
A comprehensive calorimetric, spectroscopic, and molecular docking investigation to probe the interaction of colchicine with HEWL
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-018-7800-z
Abstract: Colchicine (Col), a naturally occurring alkaloid, has been used as an anti-inflammatory, anti-fibrotic, and anti-tumor drug. The present study reports in vitro interaction between Col and hen egg white lysozyme (HEWL) by spectroscopy, isothermal titration… read more here.
Keywords: colchicine; hewl; spectroscopy; interaction ... See more keywords
Effect of colchicine induced tetraploidy on morphology, cytology, essential oil composition, gene expression and antioxidant activity of Citrus limon (L.) Osbeck
Sign Up to like & getrecommendations! Published in 2019 at "Physiology and Molecular Biology of Plants"
DOI: 10.1007/s12298-019-00718-9
Abstract: Citrus limon (L.) Osbeck cultivated all over the world is a valuable source of aromatic essential oil. To develop tetraploids of C. limon, four different concentration of colchicine (0.025, 0.05, 0.1 and 0.2%; w/v) and… read more here.
Keywords: essential oil; synthase; cytology; colchicine ... See more keywords
Intravital Imaging Reveals the Ameliorating Effect of Colchicine in a Photothrombotic Stroke Model via Inhibition of Neutrophil Recruitment.
Sign Up to like & getrecommendations! Published in 2022 at "Translational stroke research"
DOI: 10.1007/s12975-022-01022-7
Abstract: Although post-stroke neutrophil recruitment is known to be deleterious to neural tissues in the peri-infarct area, the precise behavior of recruited neutrophils remains elusive. In this study, potential therapeutic agents for modifying neutrophil behavior in… read more here.
Keywords: stroke; colchicine; model; neutrophil recruitment ... See more keywords
Colchicine-new horizons for an ancient drug.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of internal medicine"
DOI: 10.1016/j.ejim.2021.10.002
Abstract: Colchicine is an old, inexpensive, and relatively safe anti-inflammatory drug traditionally used in gout and over the last 50 years in familial Mediterranean fever. A search of all high-hierarchy studies (randomized controlled trials [RCTs], systematic… read more here.
Keywords: new horizons; horizons ancient; colchicine new; ancient drug ... See more keywords
Interactions of long-chain homologues of colchicine with tubulin.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.049
Abstract: Several colchicine analogues in which the N-acetyl residue has been replaced by aliphatic, straight-chain acyl moieties, have been synthesized. These compounds show high cytotoxic activity at the nanomolar level against the tumoral cell lines HT-29,… read more here.
Keywords: chain; colchicine; long chain; homologues colchicine ... See more keywords