Colchicine prodrugs and codrugs: Chemistry and bioactivities.
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DOI: 10.1016/j.ejmech.2017.12.029
Abstract: Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine… read more here.
Keywords: chemistry; colchicine prodrugs; colchicine; chemistry bioactivities ... See more keywords