Temperature controlled dual hypoxic chamber design for in vitro ischemia experiments
Sign Up to like & getrecommendations! Published in 2018 at "Biocybernetics and Biomedical Engineering"
DOI: 10.1016/j.bbe.2018.03.010
Abstract: Abstract In vitro ischemia models are designed to study various aspects of hypo-perfusion, focusing on the consequences of acute events under body temperature. Cold ischemia is less investigated even though the beneficial effects of cooling… read more here.
Keywords: temperature; ischemia; cold ischemia; vitro ischemia ... See more keywords
A closer look at donor lung expansion with different static ex vivo lung perfusion (EVLP) systems - invited commentary.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation"
DOI: 10.1097/tp.0000000000002668
Abstract: D to the donor shortage in lung transplantation, there is significant interest in ex vivo lung perfusion (EVLP) technologies for evaluating and treating organs that are typically not used for transplant. Okamoto et al reviewed… read more here.
Keywords: blood; perfusion; lung; cold ischemia ... See more keywords
Influence of Cold Ischemia Time on the Outcome of Kidney Transplants from Donors Aged 70 Years and Above—A Collaborative Transplant Study Report
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DOI: 10.1097/tp.0000000000003629
Abstract: Supplemental Digital Content is available in the text. Background. The use of kidney allografts from ≥70-y-old donors has increased persistently over the last 20 y. Prolonged cold ischemia time (CIT) is well known to increase… read more here.
Keywords: ischemia time; cold ischemia; transplant study; collaborative transplant ... See more keywords
Liproxstatin-1 Alleviates Lung Transplantation-induced Cold Ischemia-Reperfusion Injury by Inhibiting Ferroptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation"
DOI: 10.1097/tp.0000000000004638
Abstract: BACKGROUND Primary graft dysfunction, which is directly related to cold ischemia-reperfusion (CI/R) injury, is a major obstacle in lung transplantation (LTx). Ferroptosis, a novel mode of cell death elicited by iron-dependent lipid peroxidation, has been… read more here.
Keywords: cold ischemia; ltx injury; reperfusion; transplantation ... See more keywords
Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry
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DOI: 10.1097/txd.0000000000000888
Abstract: Background. Cold ischemia time (CIT) is known to impact kidney graft survival rates. We compare the impact of CIT on graft failure and mortality in circulatory death versus brain death donor kidneys and how it… read more here.
Keywords: donor kidneys; cold ischemia; circulatory death; death ... See more keywords
Pancreatic Islet Changes in Human Whole Organ Pancreas Explants: What Can Be Learned From Explanted Samples?
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000001059
Abstract: Background. Whole pancreas transplantation (Tx) is a successful treatment for type 1 diabetes resulting in independence from antidiabetic therapies. Transplant-related factors contributing to pancreatic islet failure are largely unknown; both recurring insulitis and pancreatitis have… read more here.
Keywords: islet; cold ischemia; pancreatic islet; tissue ... See more keywords
Prolonged Cold Ischemia Time Results in Local and Remote Organ Dysfunction in a Murine Model of Vascularized Composite Transplantation
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14290
Abstract: Vascularized composite allotransplantation (VCA) is a viable reconstructive option for complex tissue defects. Although grafts with a large muscular component may be uniquely susceptible to ischemia–reperfusion (I/R) syndrome, the safe cold ischemia time in VCA… read more here.
Keywords: ischemia time; model; transplantation; ischemia ... See more keywords
Does prolonged cold ischemia affect outcomes in donation after cardiac death donor kidney transplants?
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Transplantation"
DOI: 10.1111/ctr.14628
Abstract: The purpose of this study was to analyze the combined effect of cold ischemia time (CIT) and donation after cardiac death (DCD, with requisite warm ischemia time, WIT) on kidney transplant (KT) outcomes. read more here.
Keywords: donation cardiac; ischemia; cold ischemia; kidney ... See more keywords
Reducing cold ischemia time by donor liver “back‐table” preparation under continuous oxygenated machine perfusion of the portal vein
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Transplantation"
DOI: 10.1111/ctr.14762
Abstract: Cold ischemia time is a well‐known risk factor for the development of non‐anastomotic biliary strictures (NAS) after liver transplantation. End‐ischemic hypothermic oxygenated machine perfusion (HOPE) of DCD liver grafts reduces the incidence of NAS, and… read more here.
Keywords: ischemia; liver; cold ischemia; ischemia time ... See more keywords
Expanding our imagination with reanimation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiac Surgery"
DOI: 10.1111/jocs.17128
Abstract: Orthotopic heart transplant remains the gold standard for the treatment of end‐stage heart failure. A major barrier to its utilization in all patients is a scarcity of candidates for organ donation. Historically, organs were only… read more here.
Keywords: ischemia; time; cold ischemia; cardiac dcd ... See more keywords
Strategies to Restore Adenosine Triphosphate (ATP) Level After More than 20 Hours of Cold Ischemia Time in Human Marginal Kidney Grafts
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Transplantation"
DOI: 10.12659/aot.905406
Abstract: Background The persisting organ shortage in the field of transplantation recommends the use of marginal kidneys which poorly tolerate ischemic damage. Adenosine triphosphate (ATP) depletion during cold ischemia time (CIT) is considered crucial for graft… read more here.
Keywords: ischemia time; perfusion; adenosine triphosphate; time ... See more keywords