Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours
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DOI: 10.1038/s41551-020-0549-2
Abstract: Checkpoint-inhibitor (CPI) immunotherapy has achieved remarkable clinical success, yet its efficacy in ‘immunologically cold’ tumours has been modest. Interleukin-12 (IL-12) is a powerful cytokine that activates the innate and adaptive arms of the immune system;… read more here.
Keywords: collagen binding; mouse tumours; immunologically cold; cold mouse ... See more keywords