Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier‐Free Nanoassembly of Fluorinated Prodrug and siRNA
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202203019
Abstract: Chemoimmunotherapy has shown great potential to activate an immune response, but the immunosuppressive microenvironment associated with T cell exhaustion remains a challenge in cancer therapy. The proper immune‐modulatory strategy to provoke a robust immune response… read more here.
Keywords: cell; cold tumors; defense signaling; fluorinated prodrug ... See more keywords
Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004752
Abstract: Background The existence of immunologically ‘cold tumors’ frequently found across a wide spectrum of tumor types represents a significant challenge for cancer immunotherapy. Cold tumors have poor baseline pan-leukocyte infiltration, including a low prevalence of… read more here.
Keywords: immune checkpoint; cold tumors; tumor immune; gpx2 ... See more keywords
Abstract LB336: pH-sensitive polymeric micelles loading IL-12 profoundly inflame the tumor microenvironment to eradicate cold tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb336
Abstract: Background: Treatment of immunologically cold tumors is a major challenge. IL-12 can activates both innate and adaptive immunity to elicit strong antitumor immunity. Nevertheless, the poor pharmacokinetic and severe side effects of IL-12 limit the… read more here.
Keywords: micelles loading; cold tumors; eradicate cold; sensitive polymeric ... See more keywords
Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009622666220214103533
Abstract: The idea of cancer immunotherapy is to stimulate the immune system to fight tumors without destroying normal cells. One of the anticancer therapy methods, among many, is based on the use of cancer vaccines that… read more here.
Keywords: cancer vaccine; tumors clinical; cold tumors; clinical landscape ... See more keywords
TCGA RNA-seq and Tumor-Infiltrating Lymphocyte Imaging Data Reveal Cold Tumor Signatures of Invasive Ductal Carcinomas and Estrogen Receptor-Positive Human Breast Tumors
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119355
Abstract: Comparative studies of immune-active hot and immune-deserted cold tumors are critical for identifying therapeutic targets and strategies to improve immunotherapy outcomes in cancer patients. Tumors with high tumor-infiltrating lymphocytes (TILs) are likely to respond to… read more here.
Keywords: tumor infiltrating; cold tumors; rna seq; breast ... See more keywords
Challenges and exploration for immunotherapies targeting cold colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "World Journal of Gastrointestinal Oncology"
DOI: 10.4251/wjgo.v15.i1.55
Abstract: In recent years, immune checkpoint inhibitors (ICIs) have made significant breakthroughs in the treatment of various tumors, greatly improving clinical efficacy. As the fifth most common antitumor treatment strategy for patients with solid tumors after… read more here.
Keywords: cold tumors; immunotherapy; colorectal cancer; treatment ... See more keywords