Effects of a topical treatment with spleen tyrosine kinase (SYK) inhibitor in healthy subjects and patients with cold urticaria or chronic spontaneous urticaria: results of a Phase 1a/b randomised double-blind placebo-controlled study.
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DOI: 10.1111/bcp.14923
Abstract: AIM To explore the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of GSK2646264 using skin challenge models. METHODS Healthy volunteers (HV) with a positive allergen skin prick test received GSK2646264 (0.5% or 1% ww) and… read more here.
Keywords: reduction; coldu; chronic spontaneous; placebo ... See more keywords
Cold urticaria in tropics: A clinico-epidemiological study from North India.
Sign Up to like & getrecommendations! Published in 2024 at "Indian journal of dermatology, venereology and leprology"
DOI: 10.25259/ijdvl_727_2023
Abstract: Background Cold urticaria (ColdU) is classified as a subtype of chronic inducible urticaria characterised by recurring pruritic wheals and/or angioedema upon exposure to cold stimuli. However, very limited data is available on ColdU specifically among… read more here.
Keywords: cold urticaria; urticaria tropics; treatment response; coldu ... See more keywords
Cold-induced anaphylaxis: new insights into clinical and genetic characteristics
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DOI: 10.3389/fimmu.2025.1558284
Abstract: Introduction The pathogenesis of cold urticaria (ColdU) and cold-induced anaphylaxis (ColdA) remains poorly understood, and ColdA is underrepresented in anaphylaxis literature. Laboratory features to guide management are largely unknown. This study evaluated basal serum tryptase… read more here.
Keywords: scst; coldu colda; induced anaphylaxis; coldu ... See more keywords