The E. coli L‐asparaginase V27T mutant: structural and functional characterization and comparison with theoretical predictions
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DOI: 10.1002/1873-3468.14526
Abstract: Bacterial L‐asparaginases have been used for over 40 years as anticancer drugs. Ardalan et al. (Medical Hypotheses 112, 7–17, 2018) proposed that the V27T mutant of Escherichia coli type II L‐asparaginase, EcAII(V27T), should display altered biophysical and… read more here.
Keywords: ecaii v27t; asparaginase v27t; v27t; v27t mutant ... See more keywords
Protein re-surfacing of E. coli L-Asparaginase to evade pre-existing anti-drug antibodies and hypersensitivity responses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1016179
Abstract: The optimal use of many biotherapeutics is restricted by Anti-drug antibodies (ADAs) and hypersensitivity responses which can affect potency and ability to administer a treatment. Here we demonstrate that Re-surfacing can be utilized as a… read more here.
Keywords: hypersensitivity responses; pre existing; drug antibodies; anti drug ... See more keywords