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Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b00659
Abstract: Modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) comprise giant multidomain enzymes responsible for the "assembly line" biosynthesis of many genetically encoded small molecules. Site-directed mutagenesis, protein biochemical, and structural studies have focused on…
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Keywords:
targeted metabolomics;
multidomain;
domain targeted;
colibactin biosynthesis ... See more keywords