The reactivity of an unusual amidase may explain colibactin's DNA cross-linking activity.
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DOI: 10.1021/jacs.9b02453
Abstract: Certain commensal and pathogenic bacteria produce colibactin, a small molecule genotoxin that causes interstrand cross-links in host cell DNA. Though colibactin alkylates DNA, the molecular basis for cross-link formation is unclear. Here, we report that… read more here.
Keywords: colibactin; dna cross; cross; colibactin dna ... See more keywords