Prevention of colistin induced nephrotoxicity: a review of preclinical and clinical data
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2021.1933436
Abstract: ABSTRACT Introduction: The emergence of antimicrobial resistance in Gram-negative bacteria is a concerning challenge for health systems. The polymyxins, including colistin, are one of the limited available options these pathogens management. Nephrotoxicity, beside neurotoxicity is… read more here.
Keywords: colistin; human studies; colistin induced; review ... See more keywords
Should We Accept Colistin-Induced Nephrotoxicity To Ensure Attainment of a Therapeutic Steady State in Those with Good Renal Function?
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00351-18
Abstract: We applaud Lodise and colleagues for their recent publication addressing the pathophysiology of colistin-induced nephrotoxicity and the potential protective effect of minocycline, a broad-spectrum tetracycline antibiotic (1). Our recent experience of colistin in the treatment… read more here.
Keywords: induced nephrotoxicity; css avg; colistin; colistin induced ... See more keywords
Gelofusine Ameliorates Colistin-Induced Nephrotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00985-17
Abstract: ABSTRACT Colistin therapy is used as the last line of defense against life-threatening Gram-negative infections. Nephrotoxicity is the major dose-limiting side effect that impedes optimal dosing of patients. This study aims to examine the nephroprotective… read more here.
Keywords: gelofusine colistin; induced nephrotoxicity; colistin; gelofusine ... See more keywords
Comprehensive Assessment of Colistin Induced Nephrotoxicity: Incidence, Risk Factors and Time Course
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DOI: 10.2147/idr.s409964
Abstract: Purpose In recent years, the emergence of multidrug-resistant (MDR) microorganisms had caused the resurgence of colistin use after it was previously abandoned due to its side effects, nephrotoxicity in particular. However, the specific incidence of… read more here.
Keywords: colistin induced; incidence; risk factors; colistin ... See more keywords
METTL3/m6A/miRNA-873-5p Attenuated Oxidative Stress and Apoptosis in Colistin-Induced Kidney Injury by Modulating Keap1/Nrf2 Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00517
Abstract: Nephrotoxicity of colistin is the major factor limiting its clinical application. However, the exact mechanism of colistin-induced nephrotoxicity is still elusive. N6-Methyladenosine (m6A) modification has been implicated in many biological processes, however, its role in… read more here.
Keywords: colistin; colistin induced; m6a; stress apoptosis ... See more keywords
7-Hydroxycoumarin Attenuates Colistin-Induced Kidney Injury in Mice Through the Decreased Level of Histone Deacetylase 1 and the Activation of Nrf2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01146
Abstract: Colistin has been considered as the last line of defense against Gram-negative bacterial infections, however, the potential nephrotoxicity limited its clinical use. 7-Hydroxycoumarin (7-HC) possesses many beneļ¬cial pharmacological activities. This study aimed to investigate the… read more here.
Keywords: kidney injury; induced kidney; nrf2 signaling; histone deacetylase ... See more keywords
Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15070782
Abstract: The clinical value of colistin, a polymyxin antibiotic, is limited by its nephrotoxicity. Omeprazole is a commonly prescribed proton pump inhibitor. The current study aimed to evaluate the effects of the concomitant administration of omeprazole… read more here.
Keywords: colistin induced; nephrotoxicity rats; accumulation; colistin ... See more keywords