Prevalence of insertion sequence elements in plasmids relating to mgrB gene disruption causing colistin resistance in Klebsiella pneumoniae
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DOI: 10.1002/mbo3.1262
Abstract: Colistin is a last resort antibiotic for the treatment of carbapenemase producing Klebsiella pneumoniae. The disruption of the mgrB gene by insertion sequences (ISs) is a mechanism mediating colistin resistance. Plasmids encode mobilizable IS elements… read more here.
Keywords: mgrb gene; pneumoniae; gene; colistin resistance ... See more keywords
Mcr colistin resistance gene: a systematic review of current diagnostics and detection methods
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DOI: 10.1002/mbo3.682
Abstract: Resistance to colistin, mediated by chromosomal mutations and more recently, by plasmid‐borne mcr genes, is increasingly being reported in bacterial isolates taken from humans, animals, farms, foods, and the environment. To easily identify and contain… read more here.
Keywords: systematic review; colistin resistance; review; resistance ... See more keywords
An enzyme-free homogenous electrochemical assay for sensitive detection of the plasmid-mediated colistin resistance gene mcr-1
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-1130-7
Abstract: Antibiotic resistance associated with the mcr-1 gene of Gram-negative bacteria, which confers resistance to drugs of last resort and has the potential to spread via plasmids, is one of the most pressing issues facing global… read more here.
Keywords: enzyme free; detection; free homogenous; colistin resistance ... See more keywords
Investigation of potential risk factors for the occurrence of Escherichia coli isolates from German fattening pig farms harbouring the mcr-1 colistin-resistance gene.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.08.007
Abstract: Within the scope of a cross-sectional investigation on fattening pig farms conducted in 2011 and 2012, 48 fattening farms in different agricultural regions of Germany were sampled. Primary cultures of boot swabs and collective faecal… read more here.
Keywords: mcr colistin; colistin resistance; pig farms; fattening pig ... See more keywords
Impact of the colistin resistance gene mcr-1 on bacterial fitness.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.11.011
Abstract: A Klebsiella pneumoniae isolate harbouring a 217 kb IncHI2-type plasmid (pKP2442) encoding the colistin resistance gene mcr-1 was isolated from a leukaemia patient. pKP2442 was mobilised by intragenus and intergenus transconjugation from the clinical isolate… read more here.
Keywords: resistance gene; colistin resistance; resistance; fitness ... See more keywords
The prevalence of colistin resistance in Escherichia coli and Klebsiella pneumoniae isolated from food animals in China: coexistence of mcr-1 and blaNDM with low fitness cost.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.01.023
Abstract: Increasing colistin resistance is a global concern because colistin is used as a last resort for the treatment of carbapenem-resistant Enterobacteriaceae infections. The plasmid-mediated colistin resistance gene, mcr-1 was found in distinct bacterial species isolated… read more here.
Keywords: mcr blandm; colistin; blandm; colistin resistance ... See more keywords
Carbapenem and Colistin Resistance in Enterobacteriaceae in Southeast Asia: Review and Mapping of Emerging and Overlapping Challenges.
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DOI: 10.1016/j.ijantimicag.2019.07.019
Abstract: Carbapenem resistant Enterobacteriaceae (CRE) infections have spread globally, leaving polymyxins, including colistin, as 'treatments of last resort'. Emerging colistin resistance raises the specter of untreatable infections. Despite this threat, data remain limited for much of… read more here.
Keywords: carbapenem colistin; southeast asia; resistance; colistin resistance ... See more keywords
Colistin resistance emerges in pandrug-resistant Klebsiella pneumoniae epidemic clones in Rio de Janeiro, Brazil.
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DOI: 10.1016/j.ijantimicag.2019.08.017
Abstract: Klebsiella pneumoniae is an important human pathogen, able to accumulate and disseminate a variety of antimicrobial resistance genes. Resistance to colistin, one of the last therapeutic options for MDR bacteria, has been increasingly reported. Colistin-resistant… read more here.
Keywords: rio janeiro; klebsiella pneumoniae; resistance; colistin resistance ... See more keywords
First detection of the plasmid-mediated colistin resistance gene mcr-1 in virulent Vibrio parahaemolyticus.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of food microbiology"
DOI: 10.1016/j.ijfoodmicro.2019.108290
Abstract: The plasmid-mediated colistin resistance gene mcr-1 has been identified in various Enterobacteriaceae species, which poses a great challenge to the public health. The present study aimed to investigate the prevalence of mcr-1 in Vibrio parahaemolyticus… read more here.
Keywords: parahaemolyticus; gene; plasmid mediated; colistin resistance ... See more keywords
Mobile colistin resistance gene mcr-1 is detected on an IncI1 plasmid in E. coli from meat.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2020.08.018
Abstract: OBJECTIVES Mobile colistin resistance genes (mcr) encoded on conjugative plasmids, although described only relatively recently, have been reported globally in both humans and livestock. The genes are often associated with ISApl1 which can transpose the… read more here.
Keywords: inci1 plasmid; colistin resistance; mobile colistin; mcr ... See more keywords
Decreased colistin resistance and mcr-1 prevalence in pig-derived Escherichia coli in Japan after banning colistin as a feed additive.
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DOI: 10.1016/j.jgar.2021.01.016
Abstract: BACKGROUND Antimicrobial resistance to colistin, a widely used feed additive for farm animals across the world, has raised public health concern in recent years. Since July 2018, its use as feed additive has been banned… read more here.
Keywords: colistin; colistin resistance; coli; resistance ... See more keywords