miR‐126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis‐associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13218
Abstract: Inflammatory bowel disease, characterised by chronic relapsing‐remitting colitis, is a significant risk factor for colorectal cancer (CRC). Previously, we showed that miR‐126 functions as a tumour suppressor in CRC and is inversely correlated with tumour… read more here.
Keywords: colitis associated; colitis; colorectal cancer; mir 126 ... See more keywords
Integrative computational approach identifies immune‐relevant biomarkers in ulcerative colitis
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13357
Abstract: Ulcerative colitis is a common inflammatory bowel disease with a complex genetic and immune etiology. Immune infiltration plays a vital role in the development of ulcerative colitis. To explore potential biomarkers for ulcerative colitis and… read more here.
Keywords: olfm4 dpp10; cep55 acsl1; biomarkers ulcerative; colitis ... See more keywords
Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin‐4 expression in the colonic epithelium
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DOI: 10.1002/2211-5463.13577
Abstract: Adrenomedullin (AM) is a peptide with pleiotropic physiological functions that attenuates intestinal mucosal inflammation. However, the mechanism underpinning mucosal protection by AM is not fully understood, and its effect on intestinal epithelial cells remains unclear.… read more here.
Keywords: expression; claudin expression; adrenomedullin alleviates; colitis ... See more keywords
Hydrogel Derived from Decellularized Porcine Small Intestinal Submucosa as a Physical Shielding Repaired the Gut Epithelial Barrier of Murine Ulcerative Colitis
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DOI: 10.1002/adfm.202405601
Abstract: Ulcerative colitis (UC) is associated with the shedding of the gut mucus. Decellularized porcine small intestinal submucosa (SIS‐ECM) contains numerous active forms of extracellular matrix as well as growth factors. Herein, a mucus‐mimetic hydrogel (MAG)… read more here.
Keywords: intestinal submucosa; decellularized porcine; ulcerative colitis; porcine small ... See more keywords
Probiotic‐Inspired Nanomedicine Restores Intestinal Homeostasis in Colitis by Regulating Redox Balance, Immune Responses, and the Gut Microbiome
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202207890
Abstract: Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the bacterial approach call for improvement. Inspired by the health benefits of… read more here.
Keywords: colitis; redox balance; gut microbiome; balance immune ... See more keywords
A Biomimetic Sweeping Microrobot for Active Therapy of Ulcerative Colitis
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DOI: 10.1002/adma.202402579
Abstract: Overproduction of pathogenic cell‐free DNA (cfDNA) and reactive oxygen species (ROS) plays crucial roles in the onset and perpetuation of ulcerative colitis (UC). Inspired by sweeping robots, a magnesium@polylactic acid‐glycolic acid copolymer@polyethylenimine (Mg@PLGA@PEI) microswimmer capable… read more here.
Keywords: active therapy; plga pei; cfdna; ulcerative colitis ... See more keywords
Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis
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DOI: 10.1002/advs.202205422
Abstract: Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders of the gut microbiota. Probiotics‐based therapy positively regulating the community structure of gut microbiota is regarded as an efficient intervention for UC. However,… read more here.
Keywords: gut microbiota; therapy; colitis; ulcerative colitis ... See more keywords
Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free In Vivo Assessment of Colitis.
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DOI: 10.1002/advs.202300564
Abstract: Optoacoustic imaging (OAI) enables microscale imaging of endogenous chromophores such as hemoglobin at significantly higher penetration depths compared to other optical imaging technologies. Raster-scanning optoacoustic mesoscopy (RSOM) has recently been shown to identify superficial microvascular… read more here.
Keywords: rsom; transrectal absorber; optoacoustic mesoscopy; colitis ... See more keywords
A Curcumin-Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment.
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DOI: 10.1002/advs.202300601
Abstract: Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system of these two problems has yet to be… read more here.
Keywords: ulcerative colitis; colitis; curcumin modified; modified coordination ... See more keywords
CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation
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DOI: 10.1002/advs.202401588
Abstract: Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic and molecular interactions. The Hippo signaling pathway plays a crucial role in… read more here.
Keywords: ibd crc; circhipk2; crc; translation ... See more keywords
In Vivo Assessment of Deep Vascular Patterns in Murine Colitis Using Optoacoustic Mesoscopic Imaging
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DOI: 10.1002/advs.202404618
Abstract: The analysis of vascular morphology and functionality enables the assessment of disease activity and therapeutic effects in various pathologies. Raster‐scanning optoacoustic mesoscopy (RSOM) is an imaging modality that enables the visualization of superficial vascular networks… read more here.
Keywords: using optoacoustic; vivo assessment; murine colitis; vascular patterns ... See more keywords