miR‐126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis‐associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13218
Abstract: Inflammatory bowel disease, characterised by chronic relapsing‐remitting colitis, is a significant risk factor for colorectal cancer (CRC). Previously, we showed that miR‐126 functions as a tumour suppressor in CRC and is inversely correlated with tumour… read more here.
Keywords: colitis associated; colitis; colorectal cancer; mir 126 ... See more keywords
Integrative computational approach identifies immune‐relevant biomarkers in ulcerative colitis
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13357
Abstract: Ulcerative colitis is a common inflammatory bowel disease with a complex genetic and immune etiology. Immune infiltration plays a vital role in the development of ulcerative colitis. To explore potential biomarkers for ulcerative colitis and… read more here.
Keywords: olfm4 dpp10; cep55 acsl1; biomarkers ulcerative; colitis ... See more keywords
Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin‐4 expression in the colonic epithelium
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13577
Abstract: Adrenomedullin (AM) is a peptide with pleiotropic physiological functions that attenuates intestinal mucosal inflammation. However, the mechanism underpinning mucosal protection by AM is not fully understood, and its effect on intestinal epithelial cells remains unclear.… read more here.
Keywords: expression; claudin expression; adrenomedullin alleviates; colitis ... See more keywords
Probiotic‐Inspired Nanomedicine Restores Intestinal Homeostasis in Colitis by Regulating Redox Balance, Immune Responses, and the Gut Microbiome
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DOI: 10.1002/adma.202207890
Abstract: Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the bacterial approach call for improvement. Inspired by the health benefits of… read more here.
Keywords: colitis; redox balance; gut microbiome; balance immune ... See more keywords
Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis
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DOI: 10.1002/advs.202205422
Abstract: Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders of the gut microbiota. Probiotics‐based therapy positively regulating the community structure of gut microbiota is regarded as an efficient intervention for UC. However,… read more here.
Keywords: gut microbiota; therapy; colitis; ulcerative colitis ... See more keywords
Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free In Vivo Assessment of Colitis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300564
Abstract: Optoacoustic imaging (OAI) enables microscale imaging of endogenous chromophores such as hemoglobin at significantly higher penetration depths compared to other optical imaging technologies. Raster-scanning optoacoustic mesoscopy (RSOM) has recently been shown to identify superficial microvascular… read more here.
Keywords: rsom; transrectal absorber; optoacoustic mesoscopy; colitis ... See more keywords
A Curcumin-Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300601
Abstract: Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system of these two problems has yet to be… read more here.
Keywords: ulcerative colitis; colitis; curcumin modified; modified coordination ... See more keywords
Anti‐inflammatory effects of Vicenin‐2 on dextran sulfate sodium‐induced colitis in mice
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21529
Abstract: The objective of the present work was to evaluate the anti‐inflammatory effects of Vicenin‐2 on dextran sulfate sodium (DSS)‐induced colitis model. Colitis was induced in C57BL/6J mice by administration of 2% DSS in drinking water… read more here.
Keywords: anti inflammatory; inflammatory effects; dss induced; colitis ... See more keywords
Musculin is highly enriched in Th17 and IL‐22‐producing ILC3s and restrains pro‐inflammatory cytokines in murine colitis
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202048573
Abstract: The basic helix-loop-helix transcription factor Musculin (MSC, bHLHa22) is found to be highly enriched in pro-inflammatory Th17 cells, with levels correlated with stronger Th17 phenotypes. MSC is also significantly expressed in RORγt+ IL-22-producing group 3… read more here.
Keywords: musculin; highly enriched; colitis; inflammatory cytokines ... See more keywords
Infrared spectrometric biomarkers for ulcerative colitis screening using human serum samples
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202100307
Abstract: This study uses infrared spectrometry coupled with data analysis techniques to understand colitis‐induced alterations in the molecular components of serum samples. Using samples from 18 ulcerative colitis patients and 28 healthy volunteers, we assessed features… read more here.
Keywords: biomarkers ulcerative; spectrometric biomarkers; serum samples; colitis ... See more keywords
The protective effect of IL‐12/23 neutralizing antibody in sarcopenia associated with dextran sulfate sodium‐induced experimental colitis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13208
Abstract: The improvement of colitis symptoms by treatment with IL‐12/23 p40 neutralizing antibody should increase the muscle mass and the function of the sarcopenia phenotype. read more here.
Keywords: colitis; protective effect; effect neutralizing; neutralizing antibody ... See more keywords