Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.04.074
Abstract: BACKGROUND & AIMS Studies are needed to determine the mechanisms of mucosal dysregulation in patients with inflammatory bowel diseases (IBD) and differences in inflammatory responses of patients with ulcerative colitis (UC) vs Crohn's disease (CD).… read more here.
Keywords: single cell; immune cell; colitis crohn; blood ... See more keywords
Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn disease, and celiac disease.
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DOI: 10.1172/jci.insight.170181
Abstract: Ulcerative colitis (UC), Crohn's disease (CD), and celiac disease are prevalent intestinal inflammatory disorders with non-satisfactory therapeutic interventions. Analyzing patient data-driven cohorts can highlight disease pathways and new targets for interventions. Long non-coding RNAs (lncRNAs)… read more here.
Keywords: disease; crohn disease; mucosal; colitis crohn ... See more keywords
Indicators of suboptimal biologic therapy over time in patients with ulcerative colitis and Crohn's disease in the United States
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DOI: 10.1371/journal.pone.0175099
Abstract: This study assessed the occurrence of indicators for suboptimal biologic therapy among ulcerative colitis (UC) and Crohn’s disease (CD) patients over time in the United States (US). Data from a large US claims database (2005–2013)… read more here.
Keywords: indicators suboptimal; biologic therapy; suboptimal biologic; colitis crohn ... See more keywords
Assessing gastroenterologist and patient acceptance of biosimilars in ulcerative colitis and Crohn's disease across Germany
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DOI: 10.1371/journal.pone.0175826
Abstract: Objectives This study examined gastroenterologists’ motivation for prescribing biosimilars, assessed their treatment preferences in relation to prescribing behaviour, and explored patient attitudes to biosimilars. Methods Data were taken from the Adelphi Real World Biosimilars Programme,… read more here.
Keywords: colitis crohn; ulcerative colitis; crohn disease;
Treatment Pathways Leading to Biologic Therapies for Ulcerative Colitis and Crohn's Disease in the United States
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DOI: 10.14309/ctg.0000000000000128
Abstract: OBJECTIVES: Biologic therapies have been available for inflammatory bowel disease for >20 years, but patient outcomes have not changed appreciably over this time period. To better understand medication utilization for this disease, we evaluated a… read more here.
Keywords: treatment pathways; biologic therapies; treatment; colitis crohn ... See more keywords
Effects of ulcerative colitis and Crohn’s disease on neurodegenerative diseases: A Mendelian randomization study
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DOI: 10.3389/fgene.2022.846005
Abstract: Background: Both ulcerative colitis (UC) and Crohn’s disease (CD) are associated with neurodegenerative diseases (NDs) in observational studies, but the causality remains controversial. We aimed to use Mendelian randomization (MR) analysis to explore causal associations… read more here.
Keywords: disease; crohn disease; colitis crohn; analysis ... See more keywords
Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease
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DOI: 10.3389/fimmu.2022.865777
Abstract: Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control… read more here.
Keywords: expressed mirnas; crohn disease; differentially expressed; colitis crohn ... See more keywords
Development and Validation of a Deep Neural Network for Accurate Identification of Endoscopic Images From Patients With Ulcerative Colitis and Crohn's Disease
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DOI: 10.3389/fmed.2022.854677
Abstract: Background and Aim The identification of ulcerative colitis (UC) and Crohn's disease (CD) is a key element interfering with therapeutic response, but it is often difficult for less experienced endoscopists to identify UC and CD.… read more here.
Keywords: deep model; colitis crohn; model; ulcerative colitis ... See more keywords
Colitis and Crohn’s Foundation (India): a first nationwide inflammatory bowel disease registry
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DOI: 10.5217/ir.2019.09169
Abstract: Background/Aims The national registry for inflammatory bowel disease (IBD) was designed to study epidemiology and prescribing pattern of treatment of IBD in India. Methods A multicenter, cross-sectional, prospective registry was established across four geographical zones… read more here.
Keywords: bowel disease; inflammatory bowel; colitis crohn; disease ... See more keywords