Complex Trait Analyses of the Collaborative Cross: Tools and Databases.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6427-7_5
Abstract: The Collaborative cross (CC) is a powerful mouse resource for investigating complex genetic traits. Here we discuss various tools and techniques for gene mapping and identification using the CC. The data analyses procedures are illustrated… read more here.
Keywords: analyses collaborative; collaborative cross; complex trait; cross ... See more keywords
Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64862-z
Abstract: Antecedent viral infection may contribute to increased susceptibility to several neurological diseases, such as multiple sclerosis and Parkinson’s disease. Variation in clinical presentations of these diseases is often associated with gender, genetic background, or a… read more here.
Keywords: presentation; collaborative cross; disease; neurological phenotypes ... See more keywords
Collaborative Cross System AI: Toward 5G System and Beyond
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DOI: 10.1109/mnet.011.2000607
Abstract: The emerging industrial verticals set new challenges for 5G and beyond systems. Indeed, the heterogeneity of the underlying technologies and the challenging and conflicting requirements of the verticals make the orchestration and management of networks… read more here.
Keywords: system; collaborative cross; cross system; network ... See more keywords
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsia"
DOI: 10.1111/epi.16617
Abstract: Animal studies remain essential for understanding mechanisms of epilepsy and identifying new therapeutic targets. However, existing animal models of epilepsy do not reflect the high level of genetic diversity found in the human population. The… read more here.
Keywords: collaborative cross; mice reveal; cross; reveal extreme ... See more keywords
Hepatic transcriptional profile reveals the role of diet and genetic backgrounds on metabolic traits in female progenitor strains of the Collaborative Cross.
Sign Up to like & getrecommendations! Published in 2021 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00140.2020
Abstract: Mice have provided critical mechanistic understandings of clinical traits underlying Metabolic Syndrome (MetSyn) and susceptibility to MetSyn in mice is known to vary among inbred strains. We investigated the diet- and strain-dependent effects on metabolic… read more here.
Keywords: strain; liver triglyceride; collaborative cross; metabolic traits ... See more keywords
Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Health Perspectives"
DOI: 10.1289/ehp788
Abstract: Background: Evaluation of interindividual variability is a challenging step in risk assessment. For most environmental pollutants, including perchloroethylene (PERC), experimental data are lacking, resulting in default assumptions being used to account for variability in toxicokinetics… read more here.
Keywords: collaborative cross; toxicokinetics toxicodynamics; variability; tca ... See more keywords
Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.
Sign Up to like & getrecommendations! Published in 2022 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1010075
Abstract: Salmonella infections typically cause self-limiting gastroenteritis, but in some individuals these bacteria can spread systemically and cause disseminated disease. Salmonella Typhimurium (STm), which causes severe systemic disease in most inbred mice, has been used as… read more here.
Keywords: stm infection; infection; typhimurium; genetics ... See more keywords
Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross
Sign Up to like & getrecommendations! Published in 2017 at "Genetics"
DOI: 10.1534/genetics.116.199596
Abstract: The goal of the Collaborative Cross (CC) project was to generate and distribute over 1000 independent mouse recombinant inbred strains derived from eight inbred founders. With inbreeding nearly complete, we estimated the extinction rate among… read more here.
Keywords: collaborative cross; extinct lines; extinction; male infertility ... See more keywords
A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.119.303013
Abstract: Host genetic diversity provides a variable selection environment and physiological context for microbiota and their interaction with host physiology. Using a highly diverse mouse population, Bubier et al. identified that Odoribacter abundance influences sleep archi-tecture… read more here.
Keywords: collaborative cross; genetics; microbiome; physiology ... See more keywords
Genetic Mapping of Behavioral Traits Using the Collaborative Cross Resource
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010682
Abstract: The complicated interactions between genetic background, environment and lifestyle factors make it difficult to study the genetic basis of complex phenotypes, such as cognition and anxiety levels, in humans. However, environmental and other factors can… read more here.
Keywords: mapping behavioral; collaborative cross; behavioral traits; genetic mapping ... See more keywords