Expression of type II collagen and aggrecan genes is regulated through distinct epigenetic modifications of their multiple enhancer elements.
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DOI: 10.1016/j.gene.2019.04.034
Abstract: To maintain normal function of cartilage tissue normally, the presence of a sufficient amount of type II collagen and aggrecan is essential, and their synthesis is tightly regulated. Therefore, understanding the mechanisms that control the… read more here.
Keywords: collagen; collagen aggrecan; enhancer elements; expression ... See more keywords
Prospective Application of Partially Digested Autologous Chondrocyte for Meniscus Tissue Engineering
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DOI: 10.3390/pharmaceutics14030605
Abstract: Background: Meniscus tissue engineering has yet to achieve clinical application because it requires chondrogenic induction and in vitro cell expansion. Contrarily, cartilage engineering from autologous chondrocytes has been successfully applied in one-stage surgery. If the… read more here.
Keywords: collagen aggrecan; meniscus; tissue engineering; collagen ... See more keywords