Structural and biochemical characterization of Clostridium perfringens pili protein B collagen‐binding domains
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14626
Abstract: Sortase‐mediated pili are flexible rod proteins composed of major and minor/tip pilins, playing important roles in the initial adhesion of bacterial cells to host tissues. The pilus shaft is formed by covalent polymerization of major… read more here.
Keywords: collagen; binding domains; tip; clostridium perfringens ... See more keywords
Utility of the von Willebrand factor collagen binding assay in the diagnosis of von Willebrand disease
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24556
Abstract: von Willebrand Disease (VWD) is the most common inherited bleeding disorder and also arises as an acquired defect (AVWS). VWD and AVWS are due to quantitative deficiencies and/or qualitative defects in von Willebrand factor (VWF),… read more here.
Keywords: von; collagen binding; diagnosis; von willebrand ... See more keywords
Studies on Vibrio mimicus derived collagenase variants providing insights into critical role(s) played by the FAXWXXT motifs in its collagen-binding domain.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109779
Abstract: Vibrio mimicus collagenase (VMC), a Class II Vibrio metalloprotease, contains an HEXXH motif in a zinc-binding catalytic domain, and two FAXWXXT motifs in its C-terminal domain, which is its collagen binding domain (CBD). To understand… read more here.
Keywords: collagenase; collagen; binding domain; collagen binding ... See more keywords
Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-020-0549-2
Abstract: Checkpoint-inhibitor (CPI) immunotherapy has achieved remarkable clinical success, yet its efficacy in ‘immunologically cold’ tumours has been modest. Interleukin-12 (IL-12) is a powerful cytokine that activates the innate and adaptive arms of the immune system;… read more here.
Keywords: collagen binding; mouse tumours; immunologically cold; cold mouse ... See more keywords
Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials science"
DOI: 10.1039/c7bm00806f
Abstract: Bladder reconstruction remains challenging for urological surgery due to lack of suitable regenerative scaffolds. In a previous study, we had used a collagen-binding basic fibroblast growth factor (CBD-bFGF) to bind bFGF to the collagen scaffold,… read more here.
Keywords: collagen; bladder regeneration; collagen binding; cbd bfgf ... See more keywords
Collagen-binding proteins: insights from the Collagen Toolkits.
Sign Up to like & getrecommendations! Published in 2019 at "Essays in biochemistry"
DOI: 10.1042/ebc20180070
Abstract: The Collagen Toolkits are libraries of 56 and 57 triple-helical synthetic peptides spanning the length of the collagen II and collagen III helices. These have been used in solid-phase binding assays to locate sites where… read more here.
Keywords: insights collagen; collagen toolkits; proteins insights; collagen ... See more keywords
The serotype a-EmaA adhesin of Aggregatibacter actinomycetemcomitans does not require O-PS synthesis for collagen binding activity
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001191
Abstract: Aggregatibacter actinomycetemcomitans , a causative agent of periodontitis and non-oral diseases, synthesizes a trimeric extracellular matrix protein adhesin A (EmaA) that mediates collagen binding and biofilm formation. EmaA is found as two molecular forms, which… read more here.
Keywords: binding activity; emaa; collagen binding;
Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw6081
Abstract: Collagen-binding ability improves serum albumin as an anti-cancer drug carrier, resulting in enhanced therapeutic efficacy. Serum albumin (SA) is used as a carrier to deliver cytotoxic agents to tumors via passive targeting. To further improve… read more here.
Keywords: collagen binding; drug; carrier; cancer ... See more keywords
Functional Analysis of the Collagen Binding Proteins of Streptococcus parasanguinis FW213
Sign Up to like & getrecommendations! Published in 2020 at "mSphere"
DOI: 10.1128/msphere.00863-20
Abstract: Bacteria generally can utilize multiple adhesins to establish themselves in the host. We found that Streptococcus parasanguinis, a dominant oral commensal and an opportunistic pathogen for subacute endocarditis, possesses at least three collagen-binding proteins that… read more here.
Keywords: spaf; parasanguinis; streptococcus parasanguinis; collagen ... See more keywords
A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.845217
Abstract: The SIRPαFc fusion protein can block the immunosuppressive CD47-SIRPα signal between macrophages and tumor cells as a decoy receptor and has demonstrated its immunotherapeutic efficacy in various tumors. However, its clinical application was limited because… read more here.
Keywords: fusion protein; sirp fusion; collagen binding; sirp ... See more keywords
Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020423
Abstract: Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic… read more here.
Keywords: gpvi; collagen; binding epitope; collagen binding ... See more keywords