Structural and biochemical characterization of Clostridium perfringens pili protein B collagen‐binding domains
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14626
Abstract: Sortase‐mediated pili are flexible rod proteins composed of major and minor/tip pilins, playing important roles in the initial adhesion of bacterial cells to host tissues. The pilus shaft is formed by covalent polymerization of major… read more here.
Keywords: collagen; binding domains; tip; clostridium perfringens ... See more keywords
Utility of the von Willebrand factor collagen binding assay in the diagnosis of von Willebrand disease
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24556
Abstract: von Willebrand Disease (VWD) is the most common inherited bleeding disorder and also arises as an acquired defect (AVWS). VWD and AVWS are due to quantitative deficiencies and/or qualitative defects in von Willebrand factor (VWF),… read more here.
Keywords: von; collagen binding; diagnosis; von willebrand ... See more keywords
Studies on Vibrio mimicus derived collagenase variants providing insights into critical role(s) played by the FAXWXXT motifs in its collagen-binding domain.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109779
Abstract: Vibrio mimicus collagenase (VMC), a Class II Vibrio metalloprotease, contains an HEXXH motif in a zinc-binding catalytic domain, and two FAXWXXT motifs in its C-terminal domain, which is its collagen binding domain (CBD). To understand… read more here.
Keywords: collagenase; collagen; binding domain; collagen binding ... See more keywords
Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-020-0549-2
Abstract: Checkpoint-inhibitor (CPI) immunotherapy has achieved remarkable clinical success, yet its efficacy in ‘immunologically cold’ tumours has been modest. Interleukin-12 (IL-12) is a powerful cytokine that activates the innate and adaptive arms of the immune system;… read more here.
Keywords: collagen binding; mouse tumours; immunologically cold; cold mouse ... See more keywords
Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials science"
DOI: 10.1039/c7bm00806f
Abstract: Bladder reconstruction remains challenging for urological surgery due to lack of suitable regenerative scaffolds. In a previous study, we had used a collagen-binding basic fibroblast growth factor (CBD-bFGF) to bind bFGF to the collagen scaffold,… read more here.
Keywords: collagen; bladder regeneration; collagen binding; cbd bfgf ... See more keywords
Collagen-binding proteins: insights from the Collagen Toolkits.
Sign Up to like & getrecommendations! Published in 2019 at "Essays in biochemistry"
DOI: 10.1042/ebc20180070
Abstract: The Collagen Toolkits are libraries of 56 and 57 triple-helical synthetic peptides spanning the length of the collagen II and collagen III helices. These have been used in solid-phase binding assays to locate sites where… read more here.
Keywords: insights collagen; collagen toolkits; proteins insights; collagen ... See more keywords
The serotype a-EmaA adhesin of Aggregatibacter actinomycetemcomitans does not require O-PS synthesis for collagen binding activity
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001191
Abstract: Aggregatibacter actinomycetemcomitans , a causative agent of periodontitis and non-oral diseases, synthesizes a trimeric extracellular matrix protein adhesin A (EmaA) that mediates collagen binding and biofilm formation. EmaA is found as two molecular forms, which… read more here.
Keywords: binding activity; emaa; collagen binding;
Ratio of Von Willebrand Collagen Binding Assay and Von Willebrand Antigen Can Predict Multimer Size in Von Willebrand Disease
Sign Up to like & getrecommendations! Published in 2025 at "Haemophilia"
DOI: 10.1111/hae.70025
Abstract: Von Willebrand disease (vWD) is a common bleeding disorder with different subtypes. Laboratory diagnosis is challenging, involving several expensive and complex assays. The von Willebrand factor (vWF) collagen binding assay (VWF:CB) has been described to… read more here.
Keywords: binding assay; willebrand; willebrand disease; collagen binding ... See more keywords
Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw6081
Abstract: Collagen-binding ability improves serum albumin as an anti-cancer drug carrier, resulting in enhanced therapeutic efficacy. Serum albumin (SA) is used as a carrier to deliver cytotoxic agents to tumors via passive targeting. To further improve… read more here.
Keywords: collagen binding; drug; carrier; cancer ... See more keywords
Functional Analysis of the Collagen Binding Proteins of Streptococcus parasanguinis FW213
Sign Up to like & getrecommendations! Published in 2020 at "mSphere"
DOI: 10.1128/msphere.00863-20
Abstract: Bacteria generally can utilize multiple adhesins to establish themselves in the host. We found that Streptococcus parasanguinis, a dominant oral commensal and an opportunistic pathogen for subacute endocarditis, possesses at least three collagen-binding proteins that… read more here.
Keywords: spaf; parasanguinis; streptococcus parasanguinis; collagen ... See more keywords
Evaluation of Streptococcus mutans strains possessing genes encoding collagen-binding proteins in the Japanese population.
Sign Up to like & getrecommendations! Published in 2025 at "BMC oral health"
DOI: 10.1186/s12903-025-07276-5
Abstract: Streptococcus mutans harbors collagen-binding protein genes, namely cnm and cbm, which are implicated in its virulence and pathogenicity in both oral and extraoral infections. Although both genes were initially identified in S. mutans isolated from… read more here.
Keywords: cnm; collagen binding; streptococcus mutans; mutans strains ... See more keywords