Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
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DOI: 10.1038/s41586-021-04057-2
Abstract: Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-negative breast cancer (TNBC)1. The extracellular matrix (ECM) contributes to immune exclusion2. However, strategies to reduce ECM abundance are largely ineffective or generate undesired outcomes3,4.… read more here.
Keywords: exclusion; immune exclusion; fibre alignment; collagen fibre ... See more keywords