A Size-Changeable Collagenase-Modified Nanoscavenger for Increasing Penetration and Retention of Nanomedicine in Deep Tumor Tissue.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.201906745
Abstract: The complex tumor microenvironment constitutes a variety of barriers to prevent nanoparticles (NPs) delivery and results in extremely low accumulation of nanomedicines in solid tumors. Here, a newly developed size-changeable collagenase-modified polymer micelle is employed… read more here.
Keywords: tumor tissue; penetration; collagenase; retention ... See more keywords
Changes in endogenous UV fluorescence and biomechanical stiffness of bovine articular cartilage after collagenase digestion are strongly correlated.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biophotonics"
DOI: 10.1002/jbio.201600093
Abstract: A significant source of morbidity in the elderly population of the United States is osteoarthritis (OA), a disease caused by the breakdown and loss of articular cartilage. The exact causes of OA remain unknown, though… read more here.
Keywords: endogenous fluorescence; collagenase; articular cartilage; digestion ... See more keywords
Evaluation of the Penetration Process of Fluorescent Collagenase Nanocapsules in a 3D Collagen Gel.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.12.022
Abstract: One of the major limitations of nanomedicine is the scarce penetration of nanoparticles in tumoral tissues. These constrains have been tried to be solved by different strategies, such as the employ of polyethyleneglycol (PEG) to… read more here.
Keywords: collagen gel; penetration; collagenase; process ... See more keywords
Studies on Vibrio mimicus derived collagenase variants providing insights into critical role(s) played by the FAXWXXT motifs in its collagen-binding domain.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109779
Abstract: Vibrio mimicus collagenase (VMC), a Class II Vibrio metalloprotease, contains an HEXXH motif in a zinc-binding catalytic domain, and two FAXWXXT motifs in its C-terminal domain, which is its collagen binding domain (CBD). To understand… read more here.
Keywords: collagenase; collagen; binding domain; collagen binding ... See more keywords
Identification and antioxidant activity of bovine bone collagen-derived novel peptides prepared by recombinant collagenase from Bacillus cereus.
Sign Up to like & getrecommendations! Published in 2021 at "Food chemistry"
DOI: 10.1016/j.foodchem.2021.129143
Abstract: Millions of tons of collagen-rich bovine bone are produced as byproducts of the consumption of beef. Hydrolyzing bovine bone collagen (BBC) is an effective measure for both increasing its added value and protecting the environment.… read more here.
Keywords: collagen; collagenase; bone collagen; bovine bone ... See more keywords
A new collagenase enzyme of the marine sponge pathogen Pseudoalteromonas agarivorans NW4327 is uniquely linked with a TonB dependent receptor.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.11.106
Abstract: The primary pathogen of the Great Barrier Reef sponge Rhopaloeides odorabile, recently identified as a novel strain (NW4327) of Pseudoalteromonas agarivorans, produced collagenase which degraded R. odorabile skeletal fibers. We now report the collagenase of… read more here.
Keywords: tonb dependent; dependent receptor; sponge; collagenase ... See more keywords
Impetuous exfoliation of tungsten disulfide into a few-layer nanoscale form due to super active collagenase biomolecules
Sign Up to like & getrecommendations! Published in 2020 at "Materials Chemistry and Physics"
DOI: 10.1016/j.matchemphys.2020.123008
Abstract: Abstract We report on the collagenase activated progressive, yet spontaneous exfoliation of the stacked tungsten disulfide (WS2) system into a few-layer form via interface engineering and taking advantage of diffusion of hydronium ions (H3O+) through… read more here.
Keywords: form; tungsten disulfide; collagenase; super active ... See more keywords
Intraperitoneal collagenase as a novel therapeutic approach in an experimental model of colorectal peritoneal carcinomatosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-79721-0
Abstract: The usefulness of local collagenase in therapeutic approaches to solid tumors has been tested recently. In this study, we evaluate the safety and efficacy of intraperitoneal collagenase associated or not to mitomycin for treatment of… read more here.
Keywords: collagenase; colorectal peritoneal; intraperitoneal collagenase; peritoneal metastases ... See more keywords
Three-Year Recurrence of Dupuytren Contracture after Needle Fasciotomy or Collagenase Injection: A Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2022 at "Plastic and Reconstructive Surgery"
DOI: 10.1097/prs.0000000000009847
Abstract: Background: In this randomized controlled trial, the authors compared the recurrence of Dupuytren disease at 3 years following needle fasciotomy or collagenase injection treatment for isolated metacarpophalangeal joint contractures. Methods: The study was conducted between… read more here.
Keywords: randomized controlled; trial; needle fasciotomy; recurrence ... See more keywords
Testing the influence of surfactant‐based wound dressings on proteinase activity
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DOI: 10.1111/iwj.12697
Abstract: Proteinases are enzymes that can digest other proteins. In chronic wounds, a sub‐class of these enzymes with the ability to degrade the extracellular matrix (matrix metalloproteinases, MMPs) have been found to both inhibit healing and… read more here.
Keywords: collagenase; surfactant based; proteinase activity; surfactant ... See more keywords
Enzymatic debridement with collagenase in wounds and ulcers: a systematic review and meta‐analysis
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DOI: 10.1111/iwj.12760
Abstract: Enzymatic debridement with collagenase is a technique that is commonly used in clinical practice. This systematic review examines the effect of collagenase on all kinds of wounds, compared to an alternative therapy, on wound healing,… read more here.
Keywords: enzymatic debridement; collagenase; systematic review; debridement collagenase ... See more keywords