Collagenase Nanoparticles Enhance the Penetration of Drugs Into Pancreatic Tumors.
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DOI: 10.1021/acsnano.9b02395
Abstract: Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system, disassembles the… read more here.
Keywords: drug penetration; pdac; penetration; collagenase nanoparticles ... See more keywords