Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
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DOI: 10.1038/nature21052
Abstract: The genome of pancreatic ductal adenocarcinoma (PDAC) frequently contains deletions of tumour suppressor gene loci, most notably SMAD4, which is homozygously deleted in nearly one-third of cases. As loss of neighbouring housekeeping genes can confer… read more here.
Keywords: cancer; collateral lethality; malic enzyme; mitochondrial malic ... See more keywords