Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms
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DOI: 10.1126/sciadv.aav7416
Abstract: Paclitaxel failure promotes collateral resistance to EGFR-targeted therapy by adaptive rewiring of the cellular stress response. Secondary drug resistance stems from dynamic clonal evolution during the development of a prior primary resistance. This collateral type… read more here.
Keywords: egfr targeted; targeted therapy; collateral resistance; acquired resistance ... See more keywords