Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.02.064
Abstract: With the aim to develop anticancer agents acting selectively against resistant tumor cells, we investigated ferrocene embedded into chalcone, aurone and flavone skeletons. These compounds were conceived and then investigated based on the concept of… read more here.
Keywords: collateral sensitivity; cancer cells; cancer; resistant cancer ... See more keywords
Novel Hybrids of 3-Substituted Coumarin and Phenylsulfonylfuroxan as Potent Antitumor Agents with Collateral Sensitivity against MCF-7/ADR.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00608
Abstract: Twenty-three new coumarin-furoxan hybrids were synthesized, which exhibited nanomole antiproliferation activities in A2780, A2780/CDDP, MCF-7/ADR, and MDA-MB-231. Among them, compound 9 showed the strongest collateral sensitivity to MCF-7/ADR with 499-fold potency compared with MCF-7. Notably,… read more here.
Keywords: mcf; compound; collateral sensitivity; mcf adr ... See more keywords
Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08529-y
Abstract: Antibiotic resistance is a major challenge to global public health. Discovery of new antibiotics is slow and to ensure proper treatment of bacterial infections new strategies are needed. One way to curb the development of… read more here.
Keywords: collateral sensitivity; ctx; drug; resistance ... See more keywords
Prediction of Cross-resistance and Collateral Sensitivity by Gene Expression profiles and Genomic Mutations
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14335-7
Abstract: In adaptive evolution, an increase in fitness to an environment is frequently accompanied by changes in fitness to other environmental conditions, called cross-resistance and sensitivity. Although the networks between fitness changes affect the course of… read more here.
Keywords: collateral sensitivity; cross resistance; resistance; resistance collateral ... See more keywords
Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry frontiers"
DOI: 10.1039/d0qi01344g
Abstract: Platinum-based therapies continue to be the main regimen used to treat non-small cell lung cancers (NSCLC), where multidrug resistance plays a key role in treatment failure and strategies to overcome this limitation are urgently sought… read more here.
Keywords: lung; collateral sensitivity; lung cancer; organometallic compounds ... See more keywords
Mutational background influences P. aeruginosa ciprofloxacin resistance evolution but preserves collateral sensitivity robustness
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109370119
Abstract: Significance Bacterial adaptation to the presence of an antibiotic often involves evolutionary trade-offs, such as increased susceptibility to other drugs (collateral sensitivity). Its exploitation to design improved therapeutic strategies is only feasible if collateral sensitivity… read more here.
Keywords: sensitivity; collateral sensitivity; background influences; resistance ... See more keywords
Antibiotic Cycling Affects Resistance Evolution Independently of Collateral Sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac257
Abstract: Abstract Antibiotic cycling has been proposed as a promising approach to slow down resistance evolution against currently employed antibiotics. It remains unclear, however, to which extent the decreased resistance evolution is the result of collateral… read more here.
Keywords: cycling; collateral sensitivity; resistance evolution; resistance ... See more keywords
Rapid and robust evolution of collateral sensitivity in Pseudomonas aeruginosa antibiotic-resistant mutants
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba5493
Abstract: Analysis of convergent collateral sensitivity phenotypes may guide the design of antibiotic therapies in P. aeruginosa infections. The analysis of trade-offs, as collateral sensitivity, associated with the acquisition of antibiotic resistance, is mainly based on… read more here.
Keywords: pseudomonas aeruginosa; collateral sensitivity; antibiotic resistant; sensitivity ... See more keywords
Alteration of adeS Contributes to Tigecycline Resistance and Collateral Sensitivity to Sulbactam in Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04594-22
Abstract: Collateral sensitivity (CS) has become an increasingly common evolutionary trade-off during adaptive bacterial evolution. Here, we report a novel combination of tigecycline (TGC) resistance and CS to sulbactam (SUL) in A. baumannii. ABSTRACT The treatment… read more here.
Keywords: tgc; collateral sensitivity; sul; resistance ... See more keywords
Assessment of Phenotype Microarray plates for rapid and high-throughput analysis of collateral sensitivity networks
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0219879
Abstract: The crisis of antimicrobial resistance is driving research into the phenomenon of collateral sensitivity. Sometimes, when a bacterium evolves resistance to one antimicrobial, it becomes sensitive to others. In this study, we have investigated the… read more here.
Keywords: collateral sensitivity; throughput; phenotype microarray; sensitivity ... See more keywords
Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9070522
Abstract: Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fatal “post-antibiotic era” are evaluated. In… read more here.
Keywords: resistance; collateral sensitivity; antimicrobial peptides; multidrug resistance ... See more keywords