Na+/H+ exchange regulatory factor 1 is required for ROMK1 K+ channel expression in the surface membrane of cultured M-1 cortical collecting duct cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.104
Abstract: The ROMK1 K+ channel, a member of the ROMK channel family, is the major candidate for the K+ secretion pathway in the renal cortical collecting duct (CCD). ROMK1 possesses a PDZ domain-binding motif at its… read more here.
Keywords: surface; romk1 channel; cortical collecting; expression ... See more keywords
A case of sarcomatoid renal collecting duct carcinoma with paraneoplastic syndrome and peripheral adhesions
Sign Up to like & getrecommendations! Published in 2020 at "Urology Case Reports"
DOI: 10.1016/j.eucr.2020.101322
Abstract: Renal sarcoma-like collecting duct cancer is a rare tumor. A 68-year-old man was admitted to the hospital due to chest tightness and back swelling. Computed tomography showed solid occupying of the superior cyst of the… read more here.
Keywords: case sarcomatoid; collecting duct; duct carcinoma; duct ... See more keywords
Protein kinase D2 regulates epithelial sodium channel activity and aldosterone non-genomic responses in renal cortical collecting duct cells
Sign Up to like & getrecommendations! Published in 2020 at "Steroids"
DOI: 10.1016/j.steroids.2019.108553
Abstract: Protein kinase D2 (PKD2) is a serine/ threonine protein kinase which plays an important role in vesicle fission at the trans-Golgi network (TGN) to coordinate subcellular trafficking with gene expression. We found that in the… read more here.
Keywords: aldosterone; protein kinase; pkd2; collecting duct ... See more keywords
The SUMOylation landscape of renal cortical collecting duct cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00306
Abstract: Protein post-translational modification by the small-ubiquitin-related-modifier (SUMO) is a mechanism that allows a diverse response of cells to stress. Five SUMO family members, SUMO1-5, are expressed in mammals. We hypothesized that because kidney epithelial cells… read more here.
Keywords: sumoylation; renal cortical; sumoylation landscape; mpkccd14 cells ... See more keywords
Electrolyte transport in the renal collecting duct and its regulation by the renin-angiotensin-aldosterone system.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical science"
DOI: 10.1042/cs20180194
Abstract: Distal nephron of the kidney plays key roles in fluid volume and electrolyte homeostasis by tightly regulating reabsorption and excretion of Na+, K+, and Cl- Studies to date demonstrate the detailed electrolyte transport mechanisms in… read more here.
Keywords: duct regulation; aldosterone; collecting duct; transport ... See more keywords
P0045GENETIC ABLATION OF NFAT5 IN THE PRINCIPAL CELLS OF THE COLLECTING DUCT LEADS TO A WATER HANDLING DEFECT
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa144.p0045
Abstract: Nuclear Factor of Activated T-Cells 5 (NFAT5), also called TonEBP/OREBP, helps protecting kidney cells from the stress of extracellular hypertonic challenge. In response to hypertonicity, NFAT5 rapidly translocates into the nucleus and enhances the transcription… read more here.
Keywords: duct leads; water; nfat5f aqp2cre; mice ... See more keywords
Bilateral kidneys involvement of collecting duct carcinoma with cystic change
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000014236
Abstract: Rationale Collecting duct carcinoma (CDC) is a rare neoplasm arising from the collecting duct and should be distinguished from other renal cell carcinomas that mostly originated from the proximal tubular epithelium and tumors originated from… read more here.
Keywords: cystic change; bilateral kidneys; collecting duct; duct carcinoma ... See more keywords
Collecting duct renin regulates potassium homeostasis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13899
Abstract: The kaliuretic action of the renin–angiotensin–aldosterone system (RAAS) is well established as highlighted by hyperkalemia side effect of RAAS inhibitors but such action is usually ascribed to systemic RAAS. The present study addresses the involvement… read more here.
Keywords: collecting duct; homeostasis; raas; renin ... See more keywords
ClC-K2 in the collecting duct intercalated cells contributes to blood pressure regulation during variations in dietary Cl-intake
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729528
Abstract: Hypertension is the major clinically relevant problem affecting millions of people in the US. The renal collecting duct is known to play a critical role in setting salt-sensitivity of blood pressure. Originally, the majority of… read more here.
Keywords: blood; physiology; blood pressure; collecting duct ... See more keywords
Piezo1 and TRPV4 complementary contribute to [Ca2+]i homeostasis in collecting duct cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729575
Abstract: Mechanical stress arising from elevated fluid flow is an important regulator of the water-electrolyte transport in the collecting duct (CD). It is well established that mechano-sensitive TRPV4 Ca2+-permeable channel mediates intracellular Ca2+ ([Ca2+]i) responses to… read more here.
Keywords: collecting duct; trpv4; physiology; piezo1 ... See more keywords
Uncovering the functional role of GPR39 in the renal collecting duct
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5794821
Abstract: G protein-coupled receptors (GPCRs) are seven transmembrane domain receptors that comprise the largest class of proteins in the mammalian genome. GPR39 is part of the ghrelin subfamily of GPCRs, and is well-expressed in the kidney… read more here.
Keywords: collecting duct; expression; physiology; gpr39 ... See more keywords