Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02190-4
Abstract: Local invasion is the initial step towards metastasis, the main cause of cancer mortality. In human colorectal cancer (CRC), malignant cells predominantly invade as cohesive collectives and may undergo partial epithelial-mesenchymal transition (pEMT) at the… read more here.
Keywords: collective invasion; canonical tgf; pemt; invasion ... See more keywords
Inhibition of AURKA kinase activity suppresses collective invasion in a microfluidic cell culture platform
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02623-1
Abstract: Tumor local invasion is the first step of metastasis cascade which remains the key obstacle for cancer therapy. Collective cell migration plays a critical role in tumor invading into surrounding tissues. In vitro assays fail… read more here.
Keywords: invasion; microfluidic cell; inhibition aurka; collective invasion ... See more keywords
Cancer stem‐like cells with hybrid epithelial/mesenchymal phenotype leading the collective invasion
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14285
Abstract: Collective invasion of cancer cells is the key process of circulating tumor cell (CTC) cluster formation, and greatly contributes to metastasis. Cancer stem‐like cells (CSC) have a distinct advantage of motility for metastatic dissemination. To… read more here.
Keywords: invasion; invasion cancer; epithelial mesenchymal; collective invasion ... See more keywords
Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aaz6197
Abstract: Specialized leader cells use stable filopodia to create linear fibronectin tracks to promote collective cancer invasion. Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here,… read more here.
Keywords: invasion; leader cells; collective invasion; fibronectin micropatterning ... See more keywords
ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-0014
Abstract: These findings reveal how an interaction between cells in different EMT states confers properties that are not induced by either EMT program alone. Defining how interactions between tumor subpopulations contribute to invasion is essential for… read more here.
Keywords: collective invasion; invasion; emt program; epithelial mesenchymal ... See more keywords
Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma
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DOI: 10.1371/journal.pone.0171341
Abstract: Collective invasion of cells plays a fundamental role in tissue growth, wound healing, immune response and cancer metastasis. This paper aimed to investigate cytokeratin-14 (CK14) expression and analyze its association with collective invasion in the… read more here.
Keywords: sacc; ck14; invasion; salivary adenoid ... See more keywords