Structural Determinants of Constitutive Activation of Gα Proteins: Transducin as a Paradigm.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.6b00813
Abstract: Heterotrimeric guanine nucleotide-binding proteins (Gα proteins) are intracellular nanomachines deputed to signal transduction. The switch-on process requires the release of bound GDP from a site at the interface between GTPase and helical domains. Nucleotide release… read more here.
Keywords: collective motions; nucleotide binding; determinants constitutive; constitutive activation ... See more keywords
Conformational Heterogeneity and Frustration of the Tumor Suppressor p53 as Tuned by Punctual Mutations
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DOI: 10.3390/ijms232012636
Abstract: The conformational heterogeneity of the p53 tumor suppressor, the wild-type (p53wt) and mutated forms, was investigated by a computational approach, including the modeling and all atoms of the molecular dynamics (MD) simulations. Four different punctual… read more here.
Keywords: frustration; tumor suppressor; punctual mutations; p53 ... See more keywords
Cell–cell and Cell–noise Interactions of Bacterial Cells in a Shallow Circular Pool and Transitions of Collective Motions
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Physical Society of Japan"
DOI: 10.7566/jpsj.88.054005
Abstract: We have experimentally investigated the transitions of collective motions of bacterial cells in a shallow circular pool using the bacterial species $Bacillus$ $subtilis$. In our previous paper, we reported that the collective motions were classified… read more here.
Keywords: pool; bacterial cells; cell cell; transitions collective ... See more keywords