First Nerve‐Related Immunoprobe for Guidance of Renal Denervation through Colocalization of NIR‐II and Photoacoustic Bioimaging
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201212
Abstract: Nerve‐related fluorophores generally locate in the visible or near‐infrared region with shallow penetration depth and easy uptake by surrounding tissues. Prolonging the optical window promotes resolution by minimizing photoscattering and eliminating autofluorescence for NIR‐II (second… read more here.
Keywords: first nerve; nerve related; photoacoustic bioimaging; colocalization ... See more keywords
eQTL Colocalization Analyses Identify NTN4 as a Candidate Breast Cancer Risk Gene.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.08.006
Abstract: Breast cancer genome-wide association studies (GWASs) have identified 150 genomic risk regions containing more than 13,000 credible causal variants (CCVs). The CCVs are predominantly noncoding and enriched in regulatory elements. However, the genes underlying breast… read more here.
Keywords: cancer; cancer risk; colocalization; breast cancer ... See more keywords
Probabilistic colocalization of genetic variants from complex and molecular traits: promise and limitations.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.11.012
Abstract: Colocalization analysis has emerged as a powerful tool to uncover the overlapping of causal variants responsible for both molecular and complex disease phenotypes. The findings from colocalization analysis yield insights into the molecular pathways of… read more here.
Keywords: promise limitations; colocalization analysis; analysis; colocalization genetic ... See more keywords
A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Human Genetics"
DOI: 10.1016/j.ajhg.2021.12.012
Abstract: Mucus obstruction is a central feature in the cystic fibrosis (CF) airways. A genome-wide association study (GWAS) of lung disease by the CF Gene Modifier Consortium (CFGMC) identified a significant locus containing two mucin genes,… read more here.
Keywords: lung disease; cystic fibrosis; colocalization; locus ... See more keywords
Colocalization of association signals at nicotinic acetylcholine receptor genes between schizophrenia and smoking traits.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2021.108517
Abstract: BACKGROUND Epidemiological data suggest that smoking may be a risk factor for schizophrenia (SCZ), but more evidence is needed. Two regions coding nicotinic acetylcholine receptor (nAchR) subunits, atCHRNA2 and the CHRNA5/A3/B4 cluster, were associated with… read more here.
Keywords: smoking behaviors; nicotinic acetylcholine; association; scz smoking ... See more keywords
Ultrasensitive Fluorescence Detection and Accurate Colocalization Visualization of Dual-miRNAs in Cancer Cells Based on the Conjugated Chain Reaction of Multifunctional Pentagon DNA Nanostructures.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01063
Abstract: Herein, a multifunctional pentagon DNA nanostructure (MPDN) was assembled by the hybridization of a circular DNA scaffold containing five different fragments with five diverse DNA oligonucleotides for simultaneous sensitive detection and accurate colocalization imaging of… read more here.
Keywords: dna; colocalization; detection; cancer cells ... See more keywords
Visualizing Single-Nucleotide Variations in a Nuclear Genome Using Colocalization of Dual-Engineered CRISPR Probes.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01208
Abstract: Direct visualization of single-nucleotide variation (SNV) in single cells is of great importance for understanding the spatial organization of genomes and their relationship with cell phenotypes. Herein, we developed a new strategy for visualizing SNVs… read more here.
Keywords: nuclear genome; colocalization; using colocalization; single nucleotide ... See more keywords
EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33592-8
Abstract: Insight into the function and regulation of biological molecules can often be obtained by determining which cell structures and other molecules they localize with (i.e. colocalization). Here we describe an open source plugin for ImageJ… read more here.
Keywords: microscopy; ezcolocalization; measure colocalization; cells organisms ... See more keywords
Heterogeneity of Astrocytic and Neuronal GLT-1 at Cortical Excitatory Synapses, as Revealed by its Colocalization With Na+/K+-ATPase α Isoforms.
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral cortex"
DOI: 10.1093/cercor/bhy203
Abstract: GLT-1, the major glutamate transporter, is expressed at perisynaptic astrocytic processes (PAP) and axon terminals (AxT). GLT-1 is coupled to Na+/K+-ATPase (NKA) α1-3 isoforms, whose subcellular distribution and spatial organization in relationship to GLT-1 are… read more here.
Keywords: glt; atpase; neuronal glt; glt glt ... See more keywords
Alpha-Synuclein Deposition Within Sympathetic Noradrenergic Neurons Is Associated With Myocardial Noradrenergic Deficiency in Neurogenic Orthostatic Hypotension
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hypertensionaha.118.12642
Abstract: Lewy body diseases involve neurogenic orthostatic hypotension (nOH), cardiac noradrenergic deficiency, and deposition of the protein AS (alpha-synuclein) in sympathetic ganglion tissue. Mechanisms linking these abnormalities are poorly understood. One link may be AS deposition… read more here.
Keywords: lewy body; body; colocalization; body noh ... See more keywords
Quantifying colocalization: the MOC is a hybrid coefficient – an uninformative mix of co-occurrence and correlation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.222455
Abstract: Herein, we challenge one of the main conclusions in the Review on colocalization recently published in Journal of Cell Science ([Aaron et al., 2018][1]), that the Manders' overlap coefficient (MOC) is a valuable coefficient for… read more here.
Keywords: quantifying colocalization; moc hybrid; occurrence; coefficient ... See more keywords