Probabilistic colocalization of genetic variants from complex and molecular traits: promise and limitations.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.11.012
Abstract: Colocalization analysis has emerged as a powerful tool to uncover the overlapping of causal variants responsible for both molecular and complex disease phenotypes. The findings from colocalization analysis yield insights into the molecular pathways of… read more here.
Keywords: promise limitations; colocalization analysis; analysis; colocalization genetic ... See more keywords
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-025-01620-7
Abstract: The existing drugs for ovarian cancer (OC) are unsatisfactory and thus new drug targets are urgently required. We conducted proteome-wide Mendelian randomization (MR) and colocalization analysis to pinpoint potential targets for OC. Data on protein… read more here.
Keywords: analysis; drug targets; colocalization analysis; drug ... See more keywords