Body Composition, Inflammation, and 5-Year Outcomes in Colon Cancer
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DOI: 10.1001/jamanetworkopen.2021.15274
Abstract: Key Points Question Are underlying inflammatory pathways and body composition profiles associated with less favorable 5-year colon cancer outcomes? Findings In this cohort study including 28 patients with nonmetastatic colon cancer, high visceral fat and… read more here.
Keywords: body composition; year; cancer outcomes; colon cancer ... See more keywords
Associations Between Unprocessed Red Meat and Processed Meat With Risk of Recurrence and Mortality in Patients With Stage III Colon Cancer
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DOI: 10.1001/jamanetworkopen.2022.0145
Abstract: Key Points Question Among patients with colon cancer, is consumption of unprocessed red meat or processed meats after diagnosis associated with higher risk of recurrence and mortality? Findings In this cohort study of 1011 patients… read more here.
Keywords: red meat; unprocessed red; meat processed; colon cancer ... See more keywords
Association of Rurality, Race and Ethnicity, and Socioeconomic Status With the Surgical Management of Colon Cancer and Postoperative Outcomes Among Medicare Beneficiaries
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DOI: 10.1001/jamanetworkopen.2022.29247
Abstract: Key Points Question Is rurality associated with receipt of surgery for nonmetastatic colon cancer? Findings In this cohort study of 57 710 Medicare beneficiaries with colon cancer, rural patients were more likely to undergo surgery but… read more here.
Keywords: race; rurality; colon cancer; surgery ... See more keywords
Association of Distance, Region, and Insurance With Advanced Colon Cancer at Initial Diagnosis
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DOI: 10.1001/jamanetworkopen.2022.29954
Abstract: This cross-sectional study examines factors associated with the stage at which colon cancer is diagnosed. read more here.
Keywords: region insurance; colon cancer; distance region; association distance ... See more keywords
Pathologist Validation of a Machine Learning–Derived Feature for Colon Cancer Risk Stratification
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DOI: 10.1001/jamanetworkopen.2022.54891
Abstract: Key Points Question Can a prognostic machine learning–derived histopathologic feature be learned and validated by pathologists? Findings In this prognostic study, 2 pathologists were able to learn a machine learning–derived histopathologic feature and validate its… read more here.
Keywords: colon cancer; machine learning; feature; learning derived ... See more keywords
Mutation Frequencies in Patients With Early-Onset Colorectal Cancer.
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DOI: 10.1001/jamaoncol.2017.0084
Abstract: Mutation Frequencies in Patients With Early-Onset Colorectal Cancer To the Editor Pearlman et al1 show what can be achieved through the cooperation of cancer registries with pathologists and other clinicians. The study participants were 450… read more here.
Keywords: cancer; mutation frequencies; frequencies patients; colon cancer ... See more keywords
Role of Deficient DNA Mismatch Repair Status in Patients With Stage III Colon Cancer Treated With FOLFOX Adjuvant Chemotherapy: A Pooled Analysis From 2 Randomized Clinical Trials
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.2899
Abstract: Importance The prognostic impact of DNA mismatch repair (MMR) status in stage III colon cancer patients receiving FOLFOX (folinic acid, fluorouracil, and oxaliplatin) adjuvant chemotherapy remains controversial. Objective To determine the association of MMR status… read more here.
Keywords: status; stage iii; iii colon; colon cancer ... See more keywords
Association of Preoperative and Postoperative Serum Carcinoembryonic Antigen and Colon Cancer Outcome
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DOI: 10.1001/jamaoncol.2017.4420
Abstract: Importance Guidelines recommend measuring preoperative carcinoembryonic antigen (CEA) in patients with colon cancer. Although persistently elevated CEA after surgery has been associated with increased risk for metastatic disease, prognostic significance of elevated preoperative CEA that… read more here.
Keywords: postoperative cea; cea; colon cancer; preoperative cea ... See more keywords
Comparing Trial and Real-world Adjuvant Oxaliplatin Delivery in Patients With Stage III Colon Cancer Using a Longitudinal Cumulative Dose.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.4445
Abstract: Importance Delivery of adjuvant chemotherapy can differ substantially between trial and real-world populations. Adherence metrics like relative dose intensity (RDI) cannot capture the timing of modifications and mask differences in the total amount of chemotherapy… read more here.
Keywords: oncology; trial; stage iii; colon cancer ... See more keywords
Chemotherapy Use and Survival Among Young and Middle-Aged Patients With Colon Cancer
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DOI: 10.1001/jamasurg.2016.5050
Abstract: Importance Treatment options for patients with young-onset colon cancer remain to be defined and their effects on prognosis are unclear. Objective To investigate receipt of adjuvant chemotherapy by age category (18-49, 50-64, and 65-75 years)… read more here.
Keywords: chemotherapy; postoperative systemic; colon cancer; middle aged ... See more keywords
ER stress‐related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer
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DOI: 10.1002/1878-0261.12365
Abstract: Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to… read more here.
Keywords: prognosis; cip2a; stress; colon cancer ... See more keywords