Targeting Colon Cancers with Mutated BRAF and Microsatellite Instability.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-02771-1_2
Abstract: The subgroup of colon cancer (CRC) characterized by mutation in the BRAF gene and high mutation rate in the genomic DNA sequence, known as the microsatellite instability (MSI) phenotype, accounts for roughly 10% of the… read more here.
Keywords: colon cancers; targeting colon; colon; microsatellite instability ... See more keywords
Tumour genotypes account for survival differences in right‐ and left‐sided colon cancers
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DOI: 10.1111/codi.16060
Abstract: We sought to identify genetic differences between right‐ and left‐sided colon cancers and using these differences explain lower survival in right‐sided cancers. read more here.
Keywords: sided colon; colon cancers; differences right; left sided ... See more keywords
Distinguishable Prognostic Signatures of Left- and Right-Sided Colon Cancer: a Study Based on Sequencing Data
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000491778
Abstract: Background/Aims: Left- and right-sided colon cancers are considered to be two different diseases and have altered outcomes. However, specific molecules to predict the prognosis of left- and right-sided colon cancers are currently lacking. Methods: Expression… read more here.
Keywords: right sided; left right; colon cancers; sided colon ... See more keywords
Rectal versus left-sided colon cancers: Clinicopathological differences observed in a pooled analysis of 4,182 patients enrolled to 8 clinical trials from the ARCAD database.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.675
Abstract: 675Background: Recent retrospective analysis of CALGB/SWOG 80405 showed that left-sided colon cancers (LCC) respond differently to biological therapy compared with right-sided tumors. However, differences between rectal cancers (RC) and LCC remain undefined. Herein, we report… read more here.
Keywords: colon cancers; left sided; analysis; sided colon ... See more keywords
ColotypeR: A tool to classify colon cancers by consensus molecular subtype and subtype-specific risk of recurrence.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.632
Abstract: 632Background: Colon cancer is highly heterogeneous in prognosis and response to treatment. The consensus molecular subtypes (CMS1-4, and mixed) partition colon cancers into distinct groups. CMS4 tumors, a mesenchymal subtype, have the worst prognosis and… read more here.
Keywords: colon cancers; colotyper; subtype specific; colon ... See more keywords
ASO Author Reflections: Peritoneal Metastases After Curative-Intent Radical Resection of T4 Colon Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-022-11558-5
Abstract: Peritoneal metastases (PMs) from T4 colon cancers have been previously linked with direct spread to the serosa and surrounding peritoneum. Peritoneal metastases occur in 20–40 % of patients and have previously also been associated with… read more here.
Keywords: peritoneal metastases; author reflections; resection; aso author ... See more keywords
New Histoprognostic Factors to Consider for the Staging of Colon Cancers: Tumor Deposits, Invasive Tumor Infiltration and High-Grade Budding
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043573
Abstract: Colorectal cancer is a major public health issue due to its high incidence and mortality. It is, therefore, essential to identify histological markers for prognostic purposes and to optimize the therapeutic management of patients. The… read more here.
Keywords: infiltration; colon cancers; tumor deposits; tumor ... See more keywords