Alternaria alternata Mycotoxins Activate the Aryl Hydrocarbon Receptor and Nrf2-ARE Pathway to Alter the Structure and Immune Response of Colon Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Research in Toxicology"
DOI: 10.1021/acs.chemrestox.1c00364
Abstract: After ingestion of food commodities, the gastrointestinal tract (GIT) poses the first barrier against xenobiotics and pathogens. Therefore, it is regularly confronted with external stressors potentially affecting the inflammatory response and the epithelial barrier. Alternaria… read more here.
Keywords: hydrocarbon receptor; immune response; epithelial cells; aryl hydrocarbon ... See more keywords
Protective Effects of Piceatannol on DNA Damage in Benzo[a]pyrene-Induced Human Colon Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c00874
Abstract: Evidence shows that the dietary intake of polycyclic aromatic hydrocarbons (PAHs) from food processing induces the cellular DNA damage response and leads to the development of colorectal cancer (CRC). Therefore, protecting from cellular DNA damage… read more here.
Keywords: benzo pyrene; damage; dna damage; human colon ... See more keywords
Role of tropomyosin 4 gene misregulation in colon epithelial cell tumorigenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e15184
Abstract: e15184 Background: Ordered migration of colon epithelial cells from the bottom to the top of the crypt is required for their differentiation. Because aberrant colon cell migration may contribute to early stages of colon tumorigenesis,… read more here.
Keywords: tumorigenesis; expression; colon epithelial; cell ... See more keywords
Colon epithelial injury in critically ill colectomized patients: aberration of tight junction proteins and Toll-like receptors.
Sign Up to like & getrecommendations! Published in 2017 at "Minerva anestesiologica"
DOI: 10.23736/s0375-9393.17.11715-3
Abstract: BACKGROUND Abnormal permeability and extensive epithelial injury are characteristic of colon wall damage complicating critical illness, such as sepsis, and associated with mortality. To assess mechanisms of such colon epithelial disruption, we studied expression of… read more here.
Keywords: colon; expression; epithelial injury; tight junction ... See more keywords