Multi-omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6048
Abstract: INTRODUCTION Lynch syndrome (LS) is a hereditary condition that increases the risk of colorectal (CRC) and extracolonic cancers that exhibit microsatellite instability (MSI-H). MSI-H is driven by defective mismatch repair (dMMR), and approximately 15% of… read more here.
Keywords: normal colon; expression; colon organoids; lynch syndrome ... See more keywords
Insights into Early Onset Colorectal Cancer through Analysis of Normal Colon Organoids of Familial Adenomatous Polyposis Patients
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174138
Abstract: Simple Summary The increase in early onset colorectal cancer (EOCRC) rates places a new, heavy burden on a younger population. Current studies in EOCRC are often affected by factors such as increased cellular heterogeneity, which… read more here.
Keywords: early onset; eocrc; colon organoids; crc ... See more keywords