Starch film-coated microparticles for oral colon-specific drug delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.03.025
Abstract: The aim of this study was to prepare and characterize a novel type of starch-coated microparticles (MPs) allowing site-specific delivery of bioactives to the colon. An oral colon-specific controlled-release system was developed in the form… read more here.
Keywords: oral colon; colon specific; delivery; colon ... See more keywords
Enhanced oral absorption of insulin using colon-specific nanoparticles co-modified with amphiphilic chitosan derivatives and cell-penetrating peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c8bm01485j
Abstract: In this study, amphipathic chitosan derivative (ACS) and cell-penetrating peptide (CPP) co-modified colon-specific nanoparticles (CS-CPP NPs) were prepared and evaluated to improve the oral bioavailability of protein and peptide drugs. ACS modification was harnessed to… read more here.
Keywords: colon specific; tdcs; colon; cell penetrating ... See more keywords
Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2108163
Abstract: Abstract Compelling data have indicated menopause-associated increase in cardiovascular disease in women, while the underlying mechanisms remain largely unknown. It is established that changes of intestinal microbiota affect cardiovascular function in the context of metabolic… read more here.
Keywords: specific delivery; mir 155; function; microbiota ... See more keywords
Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale Research Letters"
DOI: 10.1186/s11671-020-03351-8
Abstract: An enzyme-responsive colon-specific delivery system was developed based on hollow mesoporous silica spheres (HMSS) to which biodegradable chitosan (CS) was attached via cleavable azo bonds (HMSS–N=N–CS). Doxorubicin (DOX) was encapsulated in a noncrystalline state in… read more here.
Keywords: colon specific; delivery; enzyme responsive; drug ... See more keywords
Colon-specific pulsatile drug release provided by electrospun shellac nanocoating on hydrophilic amorphous composites
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s154849
Abstract: Background Colon-specific pulsatile drug release, as a combined drug controlled-release model, is a useful drug delivery manner for a series of diseases. New nanomedicines and related preparation methods are highly desired. Methods With diclofenac sodium… read more here.
Keywords: specific pulsatile; colon specific; microscopy; release ... See more keywords
Polymeric systems for colon-specific Mesalazine delivery in the intestinal bowel diseases management.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220707102912
Abstract: The anti-inflammatory 5-aminosalicylic acid (5-ASA) is the main therapeutic option used in the prevention and treatment of inflammatory bowel diseases. The upper intestinal tract performs rapid and almost complete absorption of this drug when administered… read more here.
Keywords: colon specific; bowel diseases; mesalazine; delivery ... See more keywords