What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0381-y
Abstract: This “Commentary” examines an important clinical observation that right-sided colorectal cancers appear less treatable than the left-sided cancers. The concepts of (a) the “initiation/promotion/progression” process, (b) the stem cell hypothesis, (c) the role gap junctional… read more here.
Keywords: gap; colon stem; sided lesions; colorectal cancers ... See more keywords
Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03079-4
Abstract: How mechanical stress actively impacts the physiology and pathophysiology of cells and tissues is little investigated in vivo. The colon is constantly submitted to multi-frequency spontaneous pulsatile mechanical waves, which highest frequency functions, of 2 s… read more here.
Keywords: vivo; pressure; frequency; growth ... See more keywords