Development of sinomenine hydrochloride loaded shell/core nanofibrous with pH‐responsive for colon‐targeted drug delivery
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.56040
Abstract: A series of colon‐targeted, sustained‐release, sinomenine hydrochloride (SH) loaded shell/core electrospun nanofibers are reported. The fibers have shells made of Eudragit S100 (ES‐100), and drug‐loaded cores comprising of Eudragit RS100 (ERS‐100) and SH. The essential… read more here.
Keywords: drug; release; shell core; colon targeted ... See more keywords
Development and In Vitro Evaluation of a Novel Pulsatile Drug Delivery System Containing Dexketoprofen Trometamol
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-020-09452-2
Abstract: Purpose A pulsatile drug delivery system containing dexketoprofen trometamol was designed by combining immediate release and colon-targeted mini tablets into a capsule. Methods Both immediate release and colon-targeted mini tablets were prepared by wet granulation.… read more here.
Keywords: mini tablets; dexketoprofen trometamol; colon targeted; colon ... See more keywords
Dual pH-/thermo-responsive chitosan-based hydrogels prepared using "click" chemistry for colon-targeted drug delivery applications.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.117812
Abstract: A dual pH-/thermo-responsive hydrogel was designed based on a polyelectrolyte complex of polyacrylic acid (PAA) and norbornene-functionalized chitosan (CsNb), which was synergized with chemical crosslinking using bistetrazine-poly(N-isopropyl acrylamide) (bisTz-PNIPAM). The thermo-responsive polymeric crosslinker, bisTz-PNIPAM, was… read more here.
Keywords: thermo responsive; chemistry; colon targeted; dual thermo ... See more keywords
Preparation, development and characterization of Leucaena leucocephala galactomannan (LLG) conjugated sinapic acid: A potential colon targeted prodrug.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.02.132
Abstract: Sinapic acid (SA), a widely prevalent hydroxycinnamic acid, possess numerous biological activities owing to its antioxidant property. The present study was aimed to prepare colon targeted polysaccharidic/polymeric ester prodrug of SA (a microbially triggered system)… read more here.
Keywords: llg; leucaena leucocephala; sinapic acid; colon targeted ... See more keywords
Colon-Targeted β3-Adrenoceptor Agonist Mirabegron Enhances Anticolitic Potency of the Drug via Potentiating the Nrf2-HO-1 Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.4c01041
Abstract: The selective agonist of β3-adrenergic receptor mirabegron (MBG), clinically used to treat overactive bladders, exerts beneficial effects in animal models of colitis. Here, we aimed to enhance the therapeutic activity and safety of MBG as… read more here.
Keywords: colon targeted; mbg; drug; conjugated mas ... See more keywords
Colon-Targeted Hydrogel Microsphere System Encapsulating Oleic Acid-Emodin for Crohn's Disease Treatment via Ferroptosis Inhibition.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c22525
Abstract: Crohn's disease (CD) is a relapsing, systemic inflammatory disease that primarily affects the gastrointestinal tract and is often accompanied by extraintestinal manifestations and associated immune disorders. However, current pharmacological treatments for CD encounter several challenges,… read more here.
Keywords: disease; colon targeted; crohn disease; oleic acid ... See more keywords
Effect of Source and Degree of Esterification of High Methoxyl Pectin on Oral Colon-Targeted Multiparticulated Delivery of Otilonium Bromide
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c04979
Abstract: This study aims to evaluate HM (high methoxyl) pectin from different sources (apple, citrus, and beet) with varying degrees of methyl esterification (DOE) to identify the optimal grade for colonic bacterial enzyme-triggered polymeric coatings for… read more here.
Keywords: colon targeted; methoxyl pectin; colon; drug ... See more keywords
Oral colon-targeted responsive chitosan/pectin-based nanoparticles propels the application of tofacitinib in colitis therapy
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-84322-2
Abstract: Tofacitinib (Tof), a commercially available pan-Janus kinases inhibitor, is approved for the treatment of moderate to severe ulcerative colitis. However, its clinical application is limited due to dose-dependent systemic side effects. The present study aims… read more here.
Keywords: colon targeted; oral colon; therapy; colitis ... See more keywords
Oral nanoparticles based on gellan gum/pectin for colon-targeted delivery of resveratrol
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1716374
Abstract: Abstract Nanoparticles based on gellan gum/pectin blends were designed for colon-targeted release of resveratrol (RES). Their impact on drug release rates and permeability were evaluated using Caco-2 cell model and mucus secreting triple co-culture model.… read more here.
Keywords: colon targeted; drug; gum pectin; based gellan ... See more keywords
Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible Colon-targeted delivery
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2021.1873370
Abstract: Abstract α-Mangostin-loaded mucoadhesive nanoparticles (NPs) were prepared for colon-targeted drug delivery against colorectal cancer cells using pH-dependent composite mucoadhesive NPs. Chitosan (CS) and thiolated chitosan (TCS) were used to form the NPs, following by genipin… read more here.
Keywords: chitosan thiolated; delivery; colon targeted; thiolated chitosan ... See more keywords
Nanomedicine for colon-targeted drug delivery: strategies focusing on inflammatory bowel disease and colon cancer.
Sign Up to like & getrecommendations! Published in 2024 at "Nanomedicine"
DOI: 10.1080/17435889.2024.2350356
Abstract: The nanostructured drug-delivery systems for colon-targeted drug delivery are a promising field of research for localized diseases particularly influencing the colonic region, in other words, ulcerative colitis, Crohn's disease, and colorectal cancer. There are various… read more here.
Keywords: drug; colon targeted; drug delivery; targeted drug ... See more keywords