Development and In Vitro Evaluation of a Novel Pulsatile Drug Delivery System Containing Dexketoprofen Trometamol
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmaceutical Innovation"
DOI: 10.1007/s12247-020-09452-2
Abstract: Purpose A pulsatile drug delivery system containing dexketoprofen trometamol was designed by combining immediate release and colon-targeted mini tablets into a capsule. Methods Both immediate release and colon-targeted mini tablets were prepared by wet granulation.… read more here.
Keywords: mini tablets; dexketoprofen trometamol; colon targeted; colon ... See more keywords
Dual pH-/thermo-responsive chitosan-based hydrogels prepared using "click" chemistry for colon-targeted drug delivery applications.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.117812
Abstract: A dual pH-/thermo-responsive hydrogel was designed based on a polyelectrolyte complex of polyacrylic acid (PAA) and norbornene-functionalized chitosan (CsNb), which was synergized with chemical crosslinking using bistetrazine-poly(N-isopropyl acrylamide) (bisTz-PNIPAM). The thermo-responsive polymeric crosslinker, bisTz-PNIPAM, was… read more here.
Keywords: thermo responsive; chemistry; colon targeted; dual thermo ... See more keywords
Preparation, development and characterization of Leucaena leucocephala galactomannan (LLG) conjugated sinapic acid: A potential colon targeted prodrug.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.02.132
Abstract: Sinapic acid (SA), a widely prevalent hydroxycinnamic acid, possess numerous biological activities owing to its antioxidant property. The present study was aimed to prepare colon targeted polysaccharidic/polymeric ester prodrug of SA (a microbially triggered system)… read more here.
Keywords: llg; leucaena leucocephala; sinapic acid; colon targeted ... See more keywords
Oral nanoparticles based on gellan gum/pectin for colon-targeted delivery of resveratrol
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1716374
Abstract: Abstract Nanoparticles based on gellan gum/pectin blends were designed for colon-targeted release of resveratrol (RES). Their impact on drug release rates and permeability were evaluated using Caco-2 cell model and mucus secreting triple co-culture model.… read more here.
Keywords: colon targeted; drug; gum pectin; based gellan ... See more keywords
Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible Colon-targeted delivery
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2021.1873370
Abstract: Abstract α-Mangostin-loaded mucoadhesive nanoparticles (NPs) were prepared for colon-targeted drug delivery against colorectal cancer cells using pH-dependent composite mucoadhesive NPs. Chitosan (CS) and thiolated chitosan (TCS) were used to form the NPs, following by genipin… read more here.
Keywords: chitosan thiolated; delivery; colon targeted; thiolated chitosan ... See more keywords
A Colon Targeted Delivery System for Resveratrol Enriching in pH Responsive-Model
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Sciences"
DOI: 10.15171/ps.2017.07
Abstract: Background: Resveratrol effects on the prevention and treatment of colon cancer have been well documented recently, but low solubility, rapid absorption and metabolism of resveratrol limit its beneficial effects on colon cancer. Designing a formulation… read more here.
Keywords: resveratrol; system; pectin chitosan; colon targeted ... See more keywords
Current film coating designs for colon-targeted oral delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200604170048
Abstract: Colon-targeted oral delivery has recently attracted a substantial number of studies on both systemic and local treatments. Among approaches for colonic delivery, film coatings have been demonstrated as effective elements of the drug delivery systems… read more here.
Keywords: oral delivery; delivery; colon targeted; colon ... See more keywords
UNSUCCESSFUL DELIVERY OF TETRANDRINE FROM COLON-TARGETED DOSAGE FORMS COMPRISING ALGINATE/HYDROXYPROPYL METHYLCELLULOSE AND ALGINATE–CHITOSAN BEADS
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2018.v10s1.88
Abstract: Objective: The objective of this study was to optimize the formulations of antifibrotic tetrandrine beads using alginate and various concentrations ofhydroxypropyl methylcellulose (HPMC) and chitosan.Methods: Beads were formulated with six (F1–F6) concentrations of polymer and… read more here.
Keywords: targeted dosage; tetrandrine; colon targeted; dosage forms ... See more keywords
Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11122376
Abstract: Nicotinamide phosphoribosyl transferase (NAMPT) is required to maintain the NAD+ pool, among which extracellular (e) NAMPT is associated with inflammation, mainly mediated by macrophages. However, the role of (e) NAMPT in inflammatory macrophages in ulcerative… read more here.
Keywords: chronic colitis; colitis mouse; colitis; acute chronic ... See more keywords
Compound Capecitabine Colon-Targeted Microparticle Prepared by Coaxial Electrospray for Treatment of Colon Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175690
Abstract: To improve the antitumor effect of combined capecitabine (CAP) and osimertinib (OSI) therapy and quickly and efficiently reduce tumor volumes for preoperative chemotherapy, we designed a compound CAP colon-targeted microparticle (COPMP) prepared by coaxial electrospray.… read more here.
Keywords: cap; cap osi; colon targeted; targeted microparticle ... See more keywords
Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12010068
Abstract: Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of… read more here.
Keywords: drug delivery; delivery; colon targeted; drug ... See more keywords