HOXA9 mediates and marks premalignant compartment size expansion in colonic adenomas.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz038
Abstract: The transformation of normal colonic epithelium to colorectal cancer (CRC) involves a relatively ordered progression, and understanding the molecular alterations involved may aid rational design of strategies aimed at preventing or counteracting disease. Homeobox A9… read more here.
Keywords: expression; growth; hoxa9; compartment size ... See more keywords
Unique MLH1 mutations in colonic adenomas in an obligate germline Lynch syndrome carrier
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2019-206234
Abstract: Background An obligate germline Lynch syndrome carrier had four colonic adenomas removed. Materials and methods The adenomas were evaluated for grade of dysplasia, MLH1, PMS2, MSH2 and MSH6 protein expression, microsatellite instability (MSI), BRAF, methylation… read more here.
Keywords: mlh1; grade dysplasia; colonic adenomas; lynch syndrome ... See more keywords