Dual effects of the tryptophan-derived bacterial metabolite indole on colonic epithelial cell metabolism and physiology: comparison with its co-metabolite indoxyl sulfate.
Sign Up to like & getrecommendations! Published in 2022 at "Amino acids"
DOI: 10.1007/s00726-021-03122-4
Abstract: Indole, which is produced by the intestinal microbiota from L-tryptophan, is recovered at millimolar concentrations in the human feces. Indoxyl sulfate (IS), the main indole co-metabolite, can be synthesized by the host tissues. Although indole… read more here.
Keywords: colonic epithelial; indole; physiology; cell ... See more keywords
Alliin protects against inflammatory bowel disease by preserving the gene expression in colonic epithelial cells rather than altering gut microbiota
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.05.048
Abstract: Abstract Inflammatory bowel disease (IBD) has affected an increasing number of people worldwide while alliin has antibiotic effects and is able to alleviate inflammation. We aim to figure out whether pre-consumption of alliin prevents IBD… read more here.
Keywords: inflammatory bowel; rather altering; colonic epithelial; gene ... See more keywords
Colonic Epithelial Surfactant Protein D Expression Correlates with Inflammation in Clinical Colonic Inflammatory Bowel Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izz009
Abstract: Background Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract. Surfactant protein D (SP-D) is expressed in the intestinal epithelium and is essential for innate host defense and regulation of inflammatory responses. Genetic… read more here.
Keywords: colonic epithelial; inflammatory bowel; disease; inflammatory ... See more keywords
Accumulation of HLA-DR4 in Colonic Epithelial Cells Causes Severe Colitis in Homozygous HLA-DR4 Transgenic Mice
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DOI: 10.1097/mib.0000000000001282
Abstract: Background: Homozygous HLA-DR4/I-Ed transgenic mice (tgm) spontaneously developed colitis similar to human ulcerative colitis. We explored whether endoplasmic reticulum stress in colonic epithelial cells due to overexpression of HLA-DR4/I-Ed was involved in the pathogenesis of… read more here.
Keywords: epithelial cells; dr4; colonic epithelial; hla dr4 ... See more keywords
Infection with genotoxin‐producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Microbiology"
DOI: 10.1111/cmi.13099
Abstract: Several commensal and pathogenic Gram‐negative bacteria produce DNA‐damaging toxins that are considered bona fide carcinogenic agents. The microbiota of colorectal cancer (CRC) patients is enriched in genotoxin‐producing bacteria, but their role in the pathogenesis of… read more here.
Keywords: epithelial cells; colonic epithelial; genotoxin producing; infection ... See more keywords
Alliin alters gut microbiota and gene expression of colonic epithelial tissues.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.12795
Abstract: Alliin is a natural organosulfur-containing phytochemical in garlic. It is possible that alliin can regulate the gut microbiota for its strong antimicrobial activity against many pathogens. Here, we assessed whether alliin impacts the distal small… read more here.
Keywords: expression; colonic epithelial; expression colonic; gut microbiota ... See more keywords
Peroxisome proliferator-activated receptors mediate phytochemical-induced upregulation of farnesoid X receptor expression and activity in colonic epithelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732115
Abstract: Introduction: The nuclear bile acid receptor, farnesoid X receptor (FXR), is expressed on intestinal epithelial cells where its potential as a new drug target for treatment of intestinal and metabolic disorders, such as chronic diarrhoea,… read more here.
Keywords: ppar; expression; physiology; epithelial cells ... See more keywords
FXR activation enhances ACE2 expression and inhibits viral-induced IL-6 release from colonic epithelial cells in vitro: implications for gastrointestinal symptoms of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733615
Abstract: Introduction: While better known for its pulmonary symptoms, SARS-CoV-2 also adversely affects the gastrointestinal tract, causing diarrhoea with evidence of inflammation. The nuclear bile acid receptor, farnesoid x receptor (FXR), is expressed in colonic epithelial… read more here.
Keywords: expression; physiology; fxr activation; epithelial cells ... See more keywords
Pectic polysaccharides derived from Hainan Rauwolfia ameliorates NLRP3-mediated colonic epithelial cell pyroptosis in ulcerative colitis.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00081.2022
Abstract: Pectic polysaccharides (PP) could exert functions on ulcerative colitis (UC), which is classified as a non-specific inflammatory disorder. This study investigated the molecular mechanism of PP derived from Rauwolfia in UC. Firstly, the dextran sodium… read more here.
Keywords: colonic epithelial; pyroptosis; cell pyroptosis; epithelial cell ... See more keywords
Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/5570731
Abstract: Background Ulcerative colitis (UC) is a chronic inflammatory disease with increasing prevalence worldwide. Barrier defect in intestinal epithelial cells (IECs) is one of the main pathogeneses in UC. Pyroptosis is a programmed lytic cell death… read more here.
Keywords: iec pyroptosis; colonic epithelial; pyroptosis; activated signaling ... See more keywords
MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.153045
Abstract: Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Myeloid translocation gene 16 (MTG16, also known as CBFA2T3) is a transcriptional corepressor expressed in the colonic… read more here.
Keywords: epithelial differentiation; transcription; mtg16; colitis ... See more keywords