Adiponectin administration alleviates DSS-induced colonic inflammation in Caco-2 cells and mice
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1155-6
Abstract: BackgroundAdiponectin, a protein hormone produced by adipose tissues, exhibits anti-inflammatory functions in various models. This study was investigated the effects of adiponectin on dextran sodium sulfate (DSS)-colonic injury, inflammation, apoptosis, and intestinal barrier dysfunction in… read more here.
Keywords: colonic inflammation; caco cells; dss induced; induced colonic ... See more keywords
TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammation
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.05.037
Abstract: Background Mature myeloid cells play a crucial role in Crohn's disease (CD) but the molecular players that regulate their functions in CD are not fully characterized. We and others have shown that TRIM33 is involved… read more here.
Keywords: role trim33; colonic inflammation; trim33; inflammation ... See more keywords
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112059119
Abstract: Significance Colonic epithelial cells protect against inflammation by forming a barrier against ingress of microbes, digestive enzymes, and metabolic waste from the lumen. Protease-activated receptor-2 (PAR2) mediates the proinflammatory and pronociceptive actions of proteases. We… read more here.
Keywords: inflammation; par2 mugfp; endocytosis; mice ... See more keywords
Effects of Consumer Antimicrobials Benzalkonium Chloride, Benzethonium Chloride, and Chloroxylenol on Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy045
Abstract: Benzalkonium chloride (BAC), benzethonium chloride (BET), and chloroxylenol (PCMX) are antimicrobial ingredients used in many consumer products and are frequently detected in the environment. In 2016, the U.S. Food and Drug Administration removed 19 antimicrobial… read more here.
Keywords: colonic inflammation; colon; consumer; benzalkonium chloride ... See more keywords
Calprotectin protects against experimental colonic inflammation in mice
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14449
Abstract: Calprotectin is a heterodimer composed of two myeloid‐related proteins, S100A8 and S100A9, that is abundant in neutrophils and monocytes/macrophages. Faecal levels of calprotectin are used routinely to monitor inflammatory bowel disease activity. read more here.
Keywords: experimental colonic; colonic inflammation; protects experimental; calprotectin ... See more keywords
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aan4116
Abstract: The commonly used antimicrobial compound triclosan increases colonic inflammation and colon cancer in mice. Triclosan triggers inflammation Antimicrobials are ubiquitous in manufactured products beyond hand soap and exist in the environment as pollutants. Triclosan exposure… read more here.
Keywords: colonic inflammation; inflammation; colon; associated colon ... See more keywords
Irritable Bowel Syndrome-Like Symptoms in Ulcerative Colitis Patients in Clinical Remission: Association with Residual Colonic Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Digestion"
DOI: 10.1159/000494412
Abstract: Ulcerative colitis (UC) patients in clinical remission often experience irritable bowel syndrome (IBS)-like symptoms. The prevalence rate of UC patients meeting the definition of IBS, such as shown by the Rome criteria, is significantly higher… read more here.
Keywords: colonic inflammation; patients clinical; inflammation; clinical remission ... See more keywords
The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Physiological Reports"
DOI: 10.14814/phy2.14456
Abstract: Increased epithelial permeability is a key feature of IBD pathogenesis and it has been proposed that agents which promote barrier function may be of therapeutic benefit. We have previously reported the secondary bile acid, ursodeoxycholic… read more here.
Keywords: bile acids; colonic inflammation; ursodeoxycholic acid; apoptosis ... See more keywords
Intestinal accumulation of silica particles in a rat model of dextran sulfate sodium-induced colitis
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Gastroenterology"
DOI: 10.20524/aog.2019.0411
Abstract: Background: Ulcerative colitis (UC) is a lifelong inflammatory bowel disease characterized by periods of intense colonic inflammation leading to debilitating symptoms. Delivery methods of current UC treatments are suboptimal and associated with side effects. Silica… read more here.
Keywords: accumulation; colonic inflammation; silica; silica particle ... See more keywords
Colonic inflammation affects myenteric alpha-synuclein in nonhuman primates
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s196552
Abstract: Background: Parkinson’s disease (PD) patients frequently present gastrointestinal (GI) dysfunction that, in many cases, predates the onset of motor symptoms. In PD, the presynaptic protein alpha-synuclein (α-syn) undergoes pathological changes, including phosphorylation and aggregation leading… read more here.
Keywords: pathology; syn; colonic inflammation; inflammation ... See more keywords
Xylooligosaccharide Modulates Gut Microbiota and Alleviates Colonic Inflammation Caused by High Fat Diet Induced Obesity
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.01601
Abstract: Obesity leads to colonic inflammation and may increase the risk of colorectal cancer. Xylooligosaccharide (XOS) exhibits strong antioxidant and excellent antibacterial properties, and can be utilized by gut microbes to maintain the ecological balance of… read more here.
Keywords: fat diet; colonic inflammation; xos; scfa content ... See more keywords