Adiponectin administration alleviates DSS-induced colonic inflammation in Caco-2 cells and mice
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1155-6
Abstract: BackgroundAdiponectin, a protein hormone produced by adipose tissues, exhibits anti-inflammatory functions in various models. This study was investigated the effects of adiponectin on dextran sodium sulfate (DSS)-colonic injury, inflammation, apoptosis, and intestinal barrier dysfunction in… read more here.
Keywords: colonic inflammation; caco cells; dss induced; induced colonic ... See more keywords
TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammation
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.05.037
Abstract: Background Mature myeloid cells play a crucial role in Crohn's disease (CD) but the molecular players that regulate their functions in CD are not fully characterized. We and others have shown that TRIM33 is involved… read more here.
Keywords: role trim33; colonic inflammation; trim33; inflammation ... See more keywords
Modulation of Gut Microbial Metabolism by Cyanidin-3-O-Glucoside in Mitigating Polystyrene-Induced Colonic Inflammation: Insights from 16S rRNA Sequencing and Metabolomics.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c08454
Abstract: Microplastics derived from plastic waste have emerged as a pervasive environmental pollutant with potential transfer and accumulation through the food chain, thus posing risks to both ecosystems and human health. The gut microbiota, tightly intertwined… read more here.
Keywords: c3g; metabolism; inflammation; colonic inflammation ... See more keywords
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112059119
Abstract: Significance Colonic epithelial cells protect against inflammation by forming a barrier against ingress of microbes, digestive enzymes, and metabolic waste from the lumen. Protease-activated receptor-2 (PAR2) mediates the proinflammatory and pronociceptive actions of proteases. We… read more here.
Keywords: inflammation; par2 mugfp; endocytosis; mice ... See more keywords
P0201 Gut Bacteria Prevotellaceae Related Lithocholic Acid Metabolism Promotes Colonic Inflammation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.0375
Abstract: The conversion of primary bile acids to secondary bile acids by the gut microbiota has been implicated in colonic inflammation. This study investigated the role of gut microbiota related bile acid metabolism in colonic inflammation… read more here.
Keywords: gut microbiota; colitis; colonic inflammation;
Effects of Consumer Antimicrobials Benzalkonium Chloride, Benzethonium Chloride, and Chloroxylenol on Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy045
Abstract: Benzalkonium chloride (BAC), benzethonium chloride (BET), and chloroxylenol (PCMX) are antimicrobial ingredients used in many consumer products and are frequently detected in the environment. In 2016, the U.S. Food and Drug Administration removed 19 antimicrobial… read more here.
Keywords: colonic inflammation; colon; consumer; benzalkonium chloride ... See more keywords
Calprotectin protects against experimental colonic inflammation in mice
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14449
Abstract: Calprotectin is a heterodimer composed of two myeloidârelated proteins, S100A8 and S100A9, that is abundant in neutrophils and monocytes/macrophages. Faecal levels of calprotectin are used routinely to monitor inflammatory bowel disease activity. read more here.
Keywords: experimental colonic; colonic inflammation; protects experimental; calprotectin ... See more keywords
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aan4116
Abstract: The commonly used antimicrobial compound triclosan increases colonic inflammation and colon cancer in mice. Triclosan triggers inflammation Antimicrobials are ubiquitous in manufactured products beyond hand soap and exist in the environment as pollutants. Triclosan exposure… read more here.
Keywords: colonic inflammation; inflammation; colon; associated colon ... See more keywords
Irritable Bowel Syndrome-Like Symptoms in Ulcerative Colitis Patients in Clinical Remission: Association with Residual Colonic Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Digestion"
DOI: 10.1159/000494412
Abstract: Ulcerative colitis (UC) patients in clinical remission often experience irritable bowel syndrome (IBS)-like symptoms. The prevalence rate of UC patients meeting the definition of IBS, such as shown by the Rome criteria, is significantly higher… read more here.
Keywords: colonic inflammation; patients clinical; inflammation; clinical remission ... See more keywords
The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Physiological Reports"
DOI: 10.14814/phy2.14456
Abstract: Increased epithelial permeability is a key feature of IBD pathogenesis and it has been proposed that agents which promote barrier function may be of therapeutic benefit. We have previously reported the secondary bile acid, ursodeoxycholic… read more here.
Keywords: bile acids; colonic inflammation; ursodeoxycholic acid; apoptosis ... See more keywords
Intestinal accumulation of silica particles in a rat model of dextran sulfate sodium-induced colitis
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Gastroenterology"
DOI: 10.20524/aog.2019.0411
Abstract: Background: Ulcerative colitis (UC) is a lifelong inflammatory bowel disease characterized by periods of intense colonic inflammation leading to debilitating symptoms. Delivery methods of current UC treatments are suboptimal and associated with side effects. Silica… read more here.
Keywords: accumulation; colonic inflammation; silica; silica particle ... See more keywords