Menthacarin induces calcium ion influx in sensory neurons, macrophages and colonic organoids of mice.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118682
Abstract: AIMS Menthacarin is a herbal combination that is clinically used for the treatment of functional gastrointestinal disorders (FGIDs). In several clinical studies, Menthacarin reduced visceral hypersensitivity-related symptoms. Pathogenesis of visceral hypersensitivity is multifactorial. This involves… read more here.
Keywords: influx sensory; ion; sensory neurons; calcium ... See more keywords
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm.4355
Abstract: With the goal of modeling human disease of the large intestine, we sought to develop an effective protocol for deriving colonic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem cells… read more here.
Keywords: stem cells; cos; drug; induced pluripotent ... See more keywords
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Gut"
DOI: 10.1136/gutjnl-2017-315920
Abstract: Objective Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the… read more here.
Keywords: serrated crc; genetic editing; organoids provides; carcinogenesis ... See more keywords
Special AT-rich sequence-binding protein 2 (SATB2) represses proximal small intestine identity in human pluripotent stem cell derived ileal and colonic organoids
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733706
Abstract: Background: Intestinal regional specification describes a process through which unique morphology and function are imparted to defined areas of the developing gastrointestinal (GI) tract. Human intestinal organoids can be generated from human pluripotent stem cells… read more here.
Keywords: cell; ileal colonic; colonic organoids; identity ... See more keywords
Genomic and epigenomic responses to aspirin in human colonic organoids.
Sign Up to like & getrecommendations! Published in 2023 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00070.2022
Abstract: BACKGROUND Aspirin (ASA) is a proven chemoprotective agent for colorectal cancer, though mechanisms underlying these effects are incompletely understood. Human organoids are an ideal system to study genomic and epigenomic host-environment interactions. We utilize human… read more here.
Keywords: human colonic; colonic organoids; genomic epigenomic; epigenomic responses ... See more keywords