Dual‐Responsive Nanogels with Cascaded Gentamicin Release and Lysosomal Escape to Combat Intracellular Small Colony Variants for Peritonitis and Sepsis Therapies
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303671
Abstract: Intracellular bacteria are the major cause of serious infections including sepsis and peritonitis, but face great challenges in fighting against the stubborn intracellular small colony variants (SCVs). Herein, the authors have developed nanogels (NGs) to… read more here.
Keywords: sepsis therapies; colony variants; small colony; intracellular small ... See more keywords
Frequency of small-colony variants and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus in cystic fibrosis patients.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.11.012
Abstract: BACKGROUND Small-colony variants (SCVs) are a distinct phenotype of Staphylococcus aureus, known for their role in chronic, difficult to treat infections, including cystic fibrosis (CF) lung disease. The goal of this study was to characterize… read more here.
Keywords: small colony; mrsa; scv mrsa; colony variants ... See more keywords
Properties and control of cold-induced small colony variants of Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2021 at "Food bioscience"
DOI: 10.1016/j.fbio.2020.100874
Abstract: Abstract Staphylococcus aureus can survive at low temperature which existed a potential risk of food safety. In this paper, the properties of cold-induced small colony variants (SCVs) were investigated including the antibiotic resistance, biofilm formation… read more here.
Keywords: staphylococcus aureus; cold induced; small colony; induced small ... See more keywords
Small Colonies, Bigger Problems? New Evidence That Staphylococcus aureus Small Colony Variants Can Worsen Lung Inflammation in Cystic Fibrosis Rats
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00413-22
Abstract: Staphylococcus aureus is the most prevalent cystic fibrosis (CF) pathogen. During chronic airway infections, S. aureus adaptation to antibiotics includes evolving small colony variants (SCVs). ABSTRACT Staphylococcus aureus is the most prevalent cystic fibrosis (CF)… read more here.
Keywords: colony variants; staphylococcus aureus; small colony; colony ... See more keywords
Transcriptome and Proteome of Methicillin-Resistant Staphylococcus aureus Small-Colony Variants Reveal Changed Metabolism and Increased Immune Evasion
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01898-22
Abstract: Small-colony variants (SCVs) of Staphylococcus aureus have drawn increasing research attention. Owing to their slow growth, atypical colony morphology, and unusual metabolic characteristics, SCVs often cause confusion in the laboratory. ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA)… read more here.
Keywords: immune evasion; colony variants; small colony; staphylococcus aureus ... See more keywords
Staphylococcus aureus Small Colony Variants (SCVs): News From a Chronic Prosthetic Joint Infection
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2019.00363
Abstract: Small colony variants (SCV) of Staphylococcus aureus have been reported as implicated in chronic infections. Here, we investigated the genomic and transcriptomic changes involved in the evolution from a wild-type to a SCV from in… read more here.
Keywords: staphylococcus aureus; small colony; infection; prosthetic joint ... See more keywords
Targeting the ATP Synthase in Staphylococcus aureus Small Colony Variants, Streptococcus pyogenes and Pathogenic Fungi
Sign Up to like & getrecommendations! Published in 2021 at "Antibiotics"
DOI: 10.3390/antibiotics10040376
Abstract: The ATP synthase has been validated as a druggable target with the approval of the ATP synthase inhibitor, bedaquiline, for treatment of drug-resistant Mycobacterium tuberculosis, a bacterial species in which the ATP synthase is essential… read more here.
Keywords: streptococcus pyogenes; atp synthase; synthase; small colony ... See more keywords
Biofilm and Small Colony Variants—An Update on Staphylococcus aureus Strategies toward Drug Resistance
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031241
Abstract: Recently, the drawbacks arising from the overuse of antibiotics have drawn growing public attention. Among them, drug-resistance (DR) and even multidrug-resistance (MDR) pose significant challenges in clinical practice. As a representative of a DR or… read more here.
Keywords: colony variants; staphylococcus aureus; small colony; resistance ... See more keywords
Detection and Impact of Staphylococcus aureus Small Colony Variants in Chronic Wounds: A Pilot Study
Sign Up to like & getrecommendations! Published in 2025 at "Pathogens"
DOI: 10.3390/pathogens14101023
Abstract: A unique phenotype of S. aureus called S. aureus small-colony variants (SA-SCVs) are a consequential contributor to multiple infectious processes. SA-SCVs are distinguishable from wild-type S. aureus (WT-SA) by their small size, slowed growth rate,… read more here.
Keywords: aureus small; chronic wounds; colony variants; small colony ... See more keywords