Three molecular pathways model colorectal carcinogenesis in Lynch syndrome
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31300
Abstract: Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes. MMR deficiency has long been regarded as a secondary event in the pathogenesis of Lynch syndrome colorectal cancers. Recently, this concept has… read more here.
Keywords: colorectal carcinogenesis; carcinogenesis lynch; colorectal cancers; mmr deficiency ... See more keywords
In Situ Point Mutation Detection in FFPE Colorectal Cancers Using the BaseScope Assay.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0623-0_22
Abstract: In situ mutation detection (ISMD) is a powerful tool for the characterization of tumor heterogeneity at cellular resolution while preserving tissue morphology and spatial context. The BaseScope assay is a novel approach to ISMD, offering… read more here.
Keywords: ffpe colorectal; basescope assay; basescope; mutation detection ... See more keywords
What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0381-y
Abstract: This “Commentary” examines an important clinical observation that right-sided colorectal cancers appear less treatable than the left-sided cancers. The concepts of (a) the “initiation/promotion/progression” process, (b) the stem cell hypothesis, (c) the role gap junctional… read more here.
Keywords: gap; colon stem; sided lesions; colorectal cancers ... See more keywords
Clinicopathologic features and prognosis of synchronous and metachronous multiple primary colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-020-02426-3
Abstract: Purpose Multiple primary colorectal cancers (MPCCs) are different from solitary colorectal cancers in many aspects, which are not well studied. The aim of this study was to clarify the clinicopathological features and prognosis of MPCCs.… read more here.
Keywords: multiple primary; colorectal; primary colorectal; colorectal cancers ... See more keywords
The Landscape of PIK3CA Mutations in Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical colorectal cancer"
DOI: 10.1016/j.clcc.2021.02.003
Abstract: BACKGROUND Colorectal cancer is one of the most common malignancies in both men and women. Despite progress in the treatment of the disease, metastatic colorectal cancer remains lethal with a median survival slightly surpassing 2… read more here.
Keywords: colorectal cancer; landscape; colorectal cancers; cancer ... See more keywords
Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology–molecular associations: clinical and biological implications
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.198
Abstract: The Cancer Genome Atlas data on colorectal carcinoma have provided a comprehensive view of the tumor’s genomic alterations and their tumorigenic roles. Tumor morphology, however, has not been fully integrated into the analysis. The aim… read more here.
Keywords: cancer genome; genome atlas; morphology; colorectal cancers ... See more keywords
Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02806-x
Abstract: The tumor suppressor gene adenomatous polyposis coli (APC) is the initiating mutation in approximately 80% of all colorectal cancers (CRC), underscoring the importance of aberrant regulation of intracellular WNT signaling in CRC development. Recent studies… read more here.
Keywords: mutation negative; microsatellite stable; colorectal cancers; mutation ... See more keywords
Triple synchronous colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "ANZ Journal of Surgery"
DOI: 10.1111/ans.14452
Abstract: Synchronous colorectal cancers are multiple malignant colorectal tumours that occur simultaneously. Incidence is rare, but not exceptional, and the importance of pre-operative identification lies in the possibility to increase the patient’s chance of cure, but… read more here.
Keywords: synchronous colorectal; pre operative; colonoscopy; colon ... See more keywords
One‐stage laparoscopy‐assisted colectomy for synchronous double colorectal cancers
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Endoscopic Surgery"
DOI: 10.1111/ases.12359
Abstract: Synchronous multiple malignant colorectal lesions are rare, and there have been very few studies about one‐stage laparoscopic operations in these cases. Here, we evaluated the short‐term outcomes of laparoscopy‐assisted colectomy (LAC) for synchronous double colorectal… read more here.
Keywords: double colorectal; one stage; colorectal cancers; synchronous double ... See more keywords
Clinicopathological significance of heterogeneic ezrin expression in poorly differentiated clusters of colorectal cancers
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DOI: 10.1111/cas.14093
Abstract: Multicellular structures, such as tumor buddings and poorly differentiated clusters (PDC), exist at the invasive front of colorectal cancers (CRC). Although it has been reported that CRC with PDC showed frequent lymph node metastases with… read more here.
Keywords: ezrin expression; poorly differentiated; pdc; differentiated clusters ... See more keywords
Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2043
Abstract: Targeting mutant KRAS signaling pathways continues to attract attention as a therapeutic strategy for KRAS-driven tumors. In this study, we exploited the power of the CRISPR-Cas9 system to identify genes affecting the tumor xenograft growth… read more here.
Keywords: genome wide; crispr; mutant kras; colorectal cancers ... See more keywords