Three molecular pathways model colorectal carcinogenesis in Lynch syndrome
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31300
Abstract: Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes. MMR deficiency has long been regarded as a secondary event in the pathogenesis of Lynch syndrome colorectal cancers. Recently, this concept has… read more here.
Keywords: colorectal carcinogenesis; carcinogenesis lynch; colorectal cancers; mmr deficiency ... See more keywords
Probiotic Lactobacillus salivarius Ren prevent dimethylhydrazine-induced colorectal cancer through protein kinase B inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10775-w
Abstract: Probiotics are known to be a potential agent for colorectal cancer (CRC) inhibition, but the precise mechanisms by which probiotic exert anti-tumorigenic effects remain to be explored. Lactobacillus salivarius (LS) Ren was isolated from centenarians… read more here.
Keywords: salivarius ren; colorectal carcinogenesis; colorectal cancer; protein kinase ... See more keywords
USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110174
Abstract: Lipogenesis plays a critical role in colorectal carcinogenesis, but precisely how remains unclear. Here, we show that ERK2 phosphorylates ME1 at T103, thereby inhibiting its polyubiquitination and proteasomal degradation and enhancing its interaction with USP19.… read more here.
Keywords: carcinogenesis; usp19 exacerbates; colorectal carcinogenesis; lipogenesis colorectal ... See more keywords
Su1976 – Impacts of Additive Food E171 (Titanium Dioxide) on the Gut Microbiota and Colorectal Carcinogenesis in ApcMIN/+ Murine Model
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1016/s0016-5085(19)38610-x
Abstract: Background and aim: Contaminant molecules could play a key role in the initiation and/or promotion of colorectal cancer (CRC) which is the second leading cause of cancer worldwide. Among the different pollutants, titanium dioxide (TiO2)… read more here.
Keywords: colorectal carcinogenesis; additive e171; microbiota; food ... See more keywords
Microbial community heterogeneity within colorectal neoplasia and its correlation with colorectal carcinogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.02.020
Abstract: BACKGROUND & AIMS Gut microbial dysbiosis has pivotal involvement in colorectal cancer (CRC). However, the intratumoural microbiota and its association with CRC progression remains elusive. Hence, we aimed to determine the microbial community architecture within… read more here.
Keywords: microbiota; heterogeneity; colorectal carcinogenesis; crc ... See more keywords
DOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2052640
Abstract: ABSTRACT Chronic inflammation and oncogenic pathway activation are key-contributing factors in colorectal cancer pathogenesis. However, colorectal intrinsic mechanisms linking these two factors in cancer development are poorly defined. Here, we show that intestinal epithelial cell… read more here.
Keywords: oncogenic pathway; colorectal cancer; activation; colorectal carcinogenesis ... See more keywords
Helicobacter pylori promotes colorectal carcinogenesis by deregulating intestinal immunity and inducing a mucus-degrading microbiota signature
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2022-328075
Abstract: Objective Helicobacter pylori infection is the most prevalent bacterial infection worldwide. Besides being the most important risk factor for gastric cancer development, epidemiological data show that infected individuals harbour a nearly twofold increased risk to… read more here.
Keywords: colorectal carcinogenesis; pylori infection; infection; helicobacter pylori ... See more keywords
Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples
Sign Up to like & getrecommendations! Published in 2018 at "Disease Markers"
DOI: 10.1155/2018/3452739
Abstract: Colorectal cancer is a malignant tumor which harmed human beings' health. The aim of this study was to explore common biomarkers associated with colorectal carcinogenesis in paired cancer and noncancer samples. At first, fifty-nine pairs… read more here.
Keywords: cancer; colorectal carcinogenesis; cancer noncancer; noncancer samples ... See more keywords
The Gut Microbiota Metabolite Urolithin B Prevents Colorectal Carcinogenesis by Remodeling Microbiota and PD-L1/HLA-B
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/6480848
Abstract: Colorectal cancer has risen to the third occurring cancer in the world. Fluorouracil (5-Fu), oxaliplatin, and cisplatin are the most effective chemotherapeutic agents for clinical chemotherapy. Nevertheless, due to chemotherapeutic drug resistance, the survival rate… read more here.
Keywords: urolithin prevents; gut; microbiota; colorectal carcinogenesis ... See more keywords
Possible predisposition for colorectal carcinogenesis due to altered gene expressions in normal appearing mucosa from patients with colorectal neoplasia
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5833-8
Abstract: BackgroundInvestigations of colorectal carcinogenesis have mainly focused on examining neoplastic tissue. With our aim of identifying potentially cancer-predisposing molecular compositions, we chose a different approach by examining endoscopically normal appearing colonic mucosa of patients with… read more here.
Keywords: mucosa patients; crn; colorectal carcinogenesis; normal appearing ... See more keywords
Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008970
Abstract: Like many other types of cancer, colorectal cancer (CRC) develops through multiple pathways of carcinogenesis. This is also true for colorectal carcinogenesis in Lynch syndrome (LS), the most common inherited CRC syndrome. However, a comprehensive… read more here.
Keywords: multiple pathways; kronecker structure; colorectal carcinogenesis; pathways colorectal ... See more keywords