The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial‐mesenchymal transition and is silenced in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28073
Abstract: In this study, we found that the phospholipase C delta1 (PLCD1) protein expression is reduced in colorectal tumor tissues compared with paired surgical margin tissues. PLCD1‐promoted CpG methylation was detected in 29/64 (45%) primary colorectal… read more here.
Keywords: colorectal tumor; phospholipase delta1; colorectal cancer; plcd1 ... See more keywords
MALDI Mass Spectrometry Imaging for Evaluation of Therapeutics in Colorectal Tumor Organoids
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-017-1851-4
Abstract: AbstractPatient-derived colorectal tumor organoids (CTOs) closely recapitulate the complex morphological, phenotypic, and genetic features observed in in vivo tumors. Therefore, evaluation of drug distribution and metabolism in this model system can provide valuable information to… read more here.
Keywords: drug; tumor organoids; colorectal tumor; mass spectrometry ... See more keywords
Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc07029d
Abstract: The M3 metalloproteases, neurolysin and THOP1, are neuropeptidases that are expressed in various tissues and metabolize neuropeptides, such as neurotensin. The biological roles of these enzymes are not well characterized, partially because the chemical tools… read more here.
Keywords: fluorogenic substrates; diagnosis; development fluorogenic; activity ... See more keywords
Therapeutic Targeting of the Colorectal Tumor Stroma.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.09.045
Abstract: Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, which all affect the tumor microenvironment (TME). Elements of the TME serve as therapeutic targets and might be used as… read more here.
Keywords: colorectal tumor; therapeutic targeting; targeting colorectal; tumor stroma ... See more keywords
M10, a novel derivative of Myricetin, prevents ulcerative colitis and colorectal tumor through attenuating robust endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2018 at "Carcinogenesis"
DOI: 10.1093/carcin/bgy057
Abstract: Chronic gut inflammation disposes to an increased risk of colitis-associated cancer. Chemoprevention is an attractive complementary strategy. We aimed to evaluate the chemopreventive effects of M10, a novel derivative of Myricetin, in the murine azoxymethane/dextran… read more here.
Keywords: colorectal tumor; chemoprevention; colitis colorectal; m10 ... See more keywords
Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw1317
Abstract: This colorectal tumor-on-chip model is an original and reliable platform for high-throughput drug screening and genetic expression. Awareness that traditional two-dimensional (2D) in vitro and nonrepresentative animal models may not completely emulate the 3D hierarchical… read more here.
Keywords: colorectal tumor; tumor chip; model; precision ... See more keywords
Automated Segmentation of Colorectal Tumor in 3D MRI Using 3D Multiscale Densely Connected Convolutional Neural Network
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Healthcare Engineering"
DOI: 10.1155/2019/1075434
Abstract: The main goal of this work is to automatically segment colorectal tumors in 3D T2-weighted (T2w) MRI with reasonable accuracy. For such a purpose, a novel deep learning-based algorithm suited for volumetric colorectal tumor segmentation… read more here.
Keywords: colorectal tumor; network; segmentation; mri ... See more keywords
Vascular Normalization Was Associated with Colorectal Tumor Regression upon Anti-PD-L1 Combinational Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/5867047
Abstract: Anti-PD-L1 therapy exhibits durable efficacy, but only in a small fraction of cancer patients. The immunosuppressive tumor microenvironment (TME) is a crucial obstacle that impedes cancer immunotherapy. Here, we found that anti-PD-L1 therapy coupled with… read more here.
Keywords: vascular normalization; tumor regression; therapy; colorectal tumor ... See more keywords
Identification of Significant Modules and Targets of Xian-Lian-Jie-Du Decoction Based on the Analysis of Transcriptomics, Proteomics and Single-Cell Transcriptomics in Colorectal Tumor
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s344861
Abstract: Purpose Colorectal cancer (CRC) remains the third most common tumor worldwide. Ulcerative colitis (UC) could cause chronic inflammation and ulcers in the colon and rectum. UC is a risk factor for a high incidence of… read more here.
Keywords: xljdd; colorectal tumor; crc; cell ... See more keywords
Metabolomic Markers of Colorectal Tumor With Different Clinicopathological Features
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00981
Abstract: Background: Colorectal cancer (CRC) is the result of complex interactions between the tumor's molecular profile and metabolites produced by its microenvironment. Despite recent studies identifying CRC molecular subtypes, a metabolite classification system is still lacking.… read more here.
Keywords: colorectal tumor; analysis; metabolomic markers; crc ... See more keywords
Expansion of Colorectal Cancer Biomarkers Based on Gut Bacteria and Viruses
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194662
Abstract: Simple Summary The current study identified microbial (including bacterial and viral) diagnostic models that could discriminate colorectal tumor patients from healthy controls, expanding the potential biomarkers for colorectal tumors. A combination of five colorectal cancer-associated… read more here.
Keywords: healthy controls; colorectal cancer; colorectal tumor; gut bacteria ... See more keywords