Predicting the micromechanics of embedded nerve fibers using a novel three-layered model of mouse distal colon and rectum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2022.105083
Abstract: Mechanotransduction plays a central role in evoking pain from the distal colon and rectum (colorectum) where embedded sensory nerve endings convert micromechanical stresses and strains into neural action potentials. The colorectum displays strong through-thickness and… read more here.
Keywords: methodology; stresses strains; colorectum; three layered ... See more keywords
Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Prevention Research"
DOI: 10.1158/1940-6207.capr-16-0286
Abstract: Guanylate cyclase C (GUCY2C) is a tumor-suppressing receptor silenced by loss of expression of its luminocrine hormones guanylin and uroguanylin early in colorectal carcinogenesis. This observation suggests oral replacement with a GUCY2C agonist may be… read more here.
Keywords: epithelial cells; colorectum; chemoprevention; oral linaclotide ... See more keywords