Self‐Assembled Supramolecular Nanoparticles for Targeted Delivery and Combination Chemotherapy
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DOI: 10.1002/cmdc.201800291
Abstract: It is challenging but imperative to merge imaging agents and small molecule therapeutics into one nanoentity for diagnosis and treatment. Herein, we constructed polymeric nanoparticles for targeted delivery and combination chemotherapy, which formed through host–guest… read more here.
Keywords: combination; combination chemotherapy; delivery; self assembled ... See more keywords
Systemic Combination Chemotherapy in Elderly Pancreatic Cancer: a Review
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DOI: 10.1007/s12029-017-9930-0
Abstract: PurposeIn recent years, significant progress in survival has been achieved using systemic combination chemotherapy in patients with pancreatic cancer. However, the elderly are largely underrepresented in clinical trials, and gains made from these may not… read more here.
Keywords: combination chemotherapy; pancreatic cancer; cancer; oncology ... See more keywords
Combination chemotherapy with gemcitabine and nab-paclitaxel for a metastatic pancreatic ductal adenocarcinoma patient undergoing hemodialysis
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Journal of Gastroenterology"
DOI: 10.1007/s12328-019-00976-w
Abstract: In cancer patients, impairment of kidney function is not uncommon. Recently, the efficacy of the combination of gemcitabine and nab-paclitaxel for pancreatic ductal adenocarcinoma (PDAC) patients has been reported, however, there is no recommendation for… read more here.
Keywords: combination chemotherapy; nab paclitaxel; gemcitabine nab;
Obinutuzumab in Combination with Chemotherapy for the First-Line Treatment of Patients with Advanced Follicular Lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacoeconomics"
DOI: 10.1007/s40273-018-0740-4
Abstract: The National Institute for Health and Care Excellence (NICE), as part of the institute’s single technology appraisal (STA) process, invited the company that makes obinutuzumab (Roche Products Limited) to submit evidence of the clinical and… read more here.
Keywords: evidence; company; combination chemotherapy; case ... See more keywords
Enhanced anticancer potency by combination chemotherapy of HT-29 cells with biodegradable, pH-sensitive nanoparticles for co-delivery of hydroxytyrosol and doxorubicin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.03.003
Abstract: Abstract A potential approach for clinical colon cancer therapy is combination chemotherapy. In this study, a biodegradable and pH-responsive nano-carrier was designed for co-delivery of Doxorubicin hydrochloride (DOX) and Hydroxytyrosol (HT) in HT-29 colon cancer… read more here.
Keywords: hydroxytyrosol; combination; combination chemotherapy; doxorubicin ... See more keywords
Monotherapy and combination chemotherapy for Chagas disease treatment: a systematic review of clinical efficacy and safety based on randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022001081
Abstract: Abstract Abstract From a systematic review framework, we analysed the clinical evidence on the effectiveness and safety of monotherapy and combination chemotherapy for Chagas disease (ChD) treatment. The research protocol was based on the Preferred… read more here.
Keywords: monotherapy combination; chemotherapy chagas; systematic review; chemotherapy ... See more keywords
Serum Metabolic Profile Alteration Reveals Response to Platinum-Based Combination Chemotherapy for Lung Cancer: Sensitive Patients Distinguished from Insensitive ones
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DOI: 10.1038/s41598-017-16085-y
Abstract: Most lung cancers are diagnosed at fairly advanced stages due to limited clinical symptoms. Platinum-based chemotherapy, either as single regimen or in combination with radiation, is one of the major recommendations for the patients. Earlier… read more here.
Keywords: chemotherapy; combination; platinum based; combination chemotherapy ... See more keywords
Supramolecular combination chemotherapy: a pH-responsive co-encapsulation drug delivery system† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0sc01756f
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DOI: 10.1039/d0sc01756f
Abstract: Most cancer chemotherapy regimens rely on the use of two or more chemotherapeutic agents. A supramolecular approach that may allow co-delivery of two drugs is described here. read more here.
Keywords: chemotherapy; chemotherapy responsive; combination chemotherapy; delivery ... See more keywords
ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-2997
Abstract: This detailed preclinical investigation, including pharmacokinetics/pharmacodynamics and dose–schedule optimizations, of AZD6738/ceralasertib alone and in combination with chemotherapy or PARP inhibitors can inform ongoing clinical efforts to treat cancer with ATR inhibitors. read more here.
Keywords: azd6738 ceralasertib; chemotherapy parp; combination chemotherapy; inhibitor ... See more keywords
Abstract B183: The WEE1 inhibitor AZD1775 in combination with chemotherapy in Asian patients with advanced solid tumors: a phase Ib study
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b183
Abstract: Background: AZD1775 is a first-in-class, potent, selective WEE1 inhibitor that has shown acceptable toxicity, linear PK, target engagement, and antitumor activity in combination with chemotherapy (phase I and II studies, both Leijen S et al.,… read more here.
Keywords: combination; wee1 inhibitor; combination chemotherapy; cohort ... See more keywords
Impact of Geriatric Assessment on the Tolerability of Combination Chemotherapy in Older Patients with Advanced Cancer: A Matched-Pair Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Oncology Research and Treatment"
DOI: 10.1159/000529097
Abstract: Because of their individual vulnerabilities, treatment decisions for older patients can be difficult. Geriatric assessment (GA) may help to select patients for systemic treatment, but its value is still unproven. Older cancer patients (≥65 years… read more here.
Keywords: cancer; group; chemotherapy; treatment ... See more keywords