Articles with "combination cisplatin" as a keyword



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Discovery of pyrimidine-bridged CA-4 CBSIs for the treatment of cervical cancer in combination with cisplatin with significantly reduced nephrotoxicity.

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Published in 2022 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2022.114271

Abstract: A series of pyrimidine-bridged CA-4 derivatives (9a-u) targeting colchicine site were designed, synthesized and evaluated. Among them, the most potent compound 9j showed favorable anti-proliferative activities against a panel of cervical cancer cells (IC50 = 0.09-0.15 μM) and… read more here.

Keywords: cervical cancer; combination cisplatin; cancer; pyrimidine bridged ... See more keywords
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Melatonin Increases the Sensitivity of Osteosarcoma Cells to Chemotherapy Drug Cisplatin.

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Published in 2022 at "Drug research"

DOI: 10.1055/a-1830-8716

Abstract: Chemotherapy, which is one of the common treatments for osteosarcoma (OS), has many side effects and in some cases has low effectiveness due to chemoresistance, hence it is vital to study new therapies for OS.… read more here.

Keywords: increases sensitivity; combination cisplatin; cisplatin; mg63 cells ... See more keywords
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Anti-Cancer Effect of Bromelain and Its Combination with Cisplatin on HN5 Cell Line (Squamous Cell Carcinoma)

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Published in 2022 at "Journal of Dentistry"

DOI: 10.30476/dentjods.2021.89577.1478

Abstract: Statement of the Problem: Squamous cell carcinoma (SCC) comprises over 90% of oral malignancies. Cisplatin, as a selective chemotherapy agent to treat SCC, has many side effects despite its high effectiveness. There are some studies… read more here.

Keywords: cell; effect; bromelain; combination ... See more keywords