Hepatotoxic combination effects of three azole fungicides in a broad dose range
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2087-6
Abstract: Single active substances of pesticides are thoroughly examined for their toxicity before approval. In this context, the liver is frequently found to be the main target organ. Since consumers are generally exposed to multiple residues… read more here.
Keywords: active substances; chemistry; dose levels; combination effects ... See more keywords
Fine-tuning the sequential drug release of nano-formulated mutual prodrugs dictates the combination effects
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00550j
Abstract: The maintenance of robust ratiometric loading of dual therapeutic agents and fine-tuning release kinetics for consistent in vitro and in vivo optimization of combination effects is vital for discovering new anticancer drug combinations and remains… read more here.
Keywords: sequential drug; combination effects; drug release; release ... See more keywords
Modeling drug combination effects via latent tensor reconstruction
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab308
Abstract: Abstract Motivation Combination therapies have emerged as a powerful treatment modality to overcome drug resistance and improve treatment efficacy. However, the number of possible drug combinations increases very rapidly with the number of individual drugs… read more here.
Keywords: combination; tensor; drug; drug combination ... See more keywords
Response envelope analysis for quantitative evaluation of drug combinations
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz091
Abstract: MOTIVATION The concept of synergy between two agents, over a century old, is important to the fields of biology, chemistry, pharmacology, and medicine. A key step in drug combination analysis is the selection of an… read more here.
Keywords: response envelope; response; analysis; drug ... See more keywords
Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects
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DOI: 10.3390/antibiotics11081014
Abstract: It is accepted that the medicinal use of complex mixtures of plant-derived bioactive compounds is more effective than purified bioactive compounds due to beneficial combination interactions. However, synergy and antagonism are very difficult to study… read more here.
Keywords: bioactive compounds; derived bioactive; combination effects; plant derived ... See more keywords
Combination Effects of Metformin and a Mixture of Lemon Balm and Dandelion on High-Fat Diet-Induced Metabolic Alterations in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11030580
Abstract: Metformin, the first-line drug for type 2 diabetes mellitus (T2DM), has additional effects on improvements of nonalcoholic fatty liver disease (NAFLD); however, there are no treatments for both T2DM and NAFLD. Previous studies have shown… read more here.
Keywords: mixture lemon; combination; combination effects; lemon balm ... See more keywords