Cobimetinib plus gemcitabine is an active combination in KRAS G12R-mutated in previously chemotherapy-treated and failed pancreatic patients.
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DOI: 10.1200/jco.2020.38.15_suppl.4642
Abstract: 4642Background: he KRAS proto-oncogene is involved in the RAS/MAPK pathway. Various G12X mutations have been examined with the most common mutations being G12D (40%), G12V (30%), and G12R (15-20%) ... read more here.
Keywords: combination kras; cobimetinib plus; active combination; plus gemcitabine ... See more keywords