MOLECULAR MECHANISMS AND COMBINATION STRATEGIES WITH PI3K AND BTK INHIBITORS TO OVERCOME INTRINSIC AND ACQUIRED RESISTANCE IN PRECLINICAL MODELS OF ABC‐DLBCL
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439_179
Abstract: The Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has demonstrated promising efficacy in a variety of hematologic malignancies. However, the precise mechanism of action of the drug remains to be fully elucidated. Tumor‐infiltrating macrophages presented in… read more here.
Keywords: inhibitor; mechanisms combination; combination strategies; btk inhibitor ... See more keywords
Revving the CAR - Combination strategies to enhance CAR T cell effectiveness.
Sign Up to like & getrecommendations! Published in 2020 at "Blood reviews"
DOI: 10.1016/j.blre.2020.100695
Abstract: Chimeric antigen receptor (CAR) T cell therapy is currently approved for treatment of refractory B-cell malignancies. Response rates in these diseases are impressive by historical standards, but most patients do not have a durable response… read more here.
Keywords: car cell; revving car; combination strategies; car combination ... See more keywords
Combination strategies for lupus nephritis: facts and controversies
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2023.2192927
Abstract: ABSTRACT Introduction There is an unmet need to improve the efficacy of therapeutic regimens in lupus nephritis (LN). Cocktail immunosuppressive therapy for the synergistic effect of individual drugs may enhance efficacy and enable dosage reduction.… read more here.
Keywords: strategies lupus; combination; lupus nephritis; facts controversies ... See more keywords
Immunotherapy and Combination Strategies in Pancreatic Cancer: Current Status and Emerging Trends
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DOI: 10.1159/000488917
Abstract: Pancreatic cancer is among the most aggressive malignancies with no effective therapeutic options thus far. Immunotherapy has recently emerged as a promising alternative for the treatment of various solid tumors. In particular, promising results in… read more here.
Keywords: emerging trends; pancreatic cancer; immunotherapy combination; combination strategies ... See more keywords
Combination Strategies Involving Immune Checkpoint Inhibitors and Tyrosine Kinase or BRAF Inhibitors in Aggressive Thyroid Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105731
Abstract: Thyroid cancer is the most common (~90%) type of endocrine-system tumor, accounting for 70% of the deaths from endocrine cancers. In the last years, the high-throughput genomics has been able to identify pathways/molecular targets involved… read more here.
Keywords: thyroid cancer; combination strategies; cancer; checkpoint inhibitors ... See more keywords
Combination strategies for pharmacologic treatment of non-alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i35.5129
Abstract: Non-alcoholic steatohepatitis (NASH) is defined as hepatic steatosis, inflammation, and hepatocyte injury with or without fibrosis. It has emerged as the second leading indication for liver transplantation with a rising death rate in the non-transplantable… read more here.
Keywords: combination strategies; non alcoholic; alcoholic steatohepatitis; strategies pharmacologic ... See more keywords