Combinatorial approaches to effective therapy in glioblastoma (GBM): Current status and what the future holds
Sign Up to like & getrecommendations! Published in 2022 at "International Reviews of Immunology"
DOI: 10.1080/08830185.2022.2101647
Abstract: Abstract The aggressive and recurrent nature of glioblastoma is multifactorial and has been attributed to its biological heterogeneity, dysfunctional metabolic signaling pathways, rigid blood–brain barrier, inherent resistance to standard therapy due to the stemness property… read more here.
Keywords: cell; glioblastoma; therapy; combinatorial approaches ... See more keywords
Combinatorial Approaches for Efficient Design of Photoswitchable Protein-Protein Interactions as In Vivo Actuators
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.844405
Abstract: Light switchable two-component protein dimerization systems offer versatile manipulation and dissection of cellular events in living systems. Over the past 20 years, the field has been driven by the discovery of photoreceptor-based interaction systems, the… read more here.
Keywords: efficient design; combinatorial approaches; design; design photoswitchable ... See more keywords
Editorial: Combinatorial Approaches to Enhance Anti-tumor Immunity: Focus on Immune Checkpoint Blockade Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02083
Abstract: One major concern when treating patients with ICBs, such as anti-PD1 and anti-CTLA-4 antibodies, is the high frequency of immune-related adverse events. This, along with lacking a reliable biomarker for patient stratification, underscores the need… read more here.
Keywords: approaches enhance; combinatorial approaches; editorial combinatorial; anti tumor ... See more keywords