Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar‐containing antibiotics
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.10.009
Abstract: Graphical abstract Figure. No Caption available. Abstract Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein,… read more here.
Keywords: biosynthesis; sugar containing; containing antibiotics; biology ... See more keywords
Combinatorial biosynthesis: playing chess with the metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2022.2065265
Abstract: Abstract Secondary metabolites are a group of natural products that produced by bacteria, fungi and plants. Many applications of these compounds from medicine to industry have been discovered. However, some changes in their structure and… read more here.
Keywords: biosynthesis; biosynthesis playing; playing chess; chess metabolism ... See more keywords
New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02453-19
Abstract: Combinatorial biosynthesis has proved its usefulness in generating derivatives of already known compounds with novel or improved pharmacological properties. Sipanmycins are a family of glycosylated macrolactams produced by Streptomyces sp. strain CS149, whose antiproliferative activity… read more here.
Keywords: mutasynthesis approaches; flexibility; sipanmycin analogues; combinatorial biosynthesis ... See more keywords
Molecular networking assisted discovery and combinatorial biosynthesis of new antimicrobial pleuromutilins.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4149497
Abstract: Pleuromutilins, the unique fungal metabolites possessing 5/6/8 tricyclic skeleton, are potent antibacterial leading compounds for the development of new antibiotics. We applied the MS/MS molecular networking technique and the combinatorial biosynthesis approach to discover new… read more here.
Keywords: assisted discovery; biosynthesis; combinatorial biosynthesis; networking assisted ... See more keywords